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D3 Receptors and Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely affects sleep. It is characterized by an urge to move the legs that is often...
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Therapeutic Applications of Dopamine D3 Receptor Function New Insight After 30 Years Of Research
The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Functionreviews the state of the knowledge on the dopamine D3 receptor and its role...
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Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders
Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related disorders where it regulates redox imbalance, inflammation,...
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D3 Receptors and PET Imaging
This chapter encapsulates a short introduction to positron emission tomography (PET) imaging and the information gained by using this technology to...
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A Historical Perspective on the Dopamine D3 Receptor
Before 1990, the multiplicity of dopamine receptors beyond D1 and D2 had remained a controversial concept, despite its substantial clinical...
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Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo
Noninvasive quantitative imaging of beta-cells can provide information on changes in cellular transporters, receptors, and signaling proteins that...
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Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression
Structural neuroplasticity in the adult brain is a process involving quantitative changes of the number and size of neurons and of their dendritic...
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Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor–Receptor Interaction and Striatal Function
G protein-coupled receptors (GPCR) heterodimers represent new entities with unique pharmacological, signalling, and trafficking properties, with...
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Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System
When the rat D3 dopamine receptor (D3R) was cloned and the distribution of its mRNA examined in 1990–1991, it attracted attention due to its peculiar...
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Impulsive-compulsive behaviour in early Parkinson’s disease is determined by apathy and dopamine receptor D3 polymorphism
Impulsive-compulsive behaviour (ICB) is a frequently observed non-motor symptom in early Parkinson’s disease after initiating dopamine replacement...
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Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease
Parkinson’s disease (PD), which is traditionally viewed as a motor disorder involving the degeneration of dopaminergic (DA) neurons, has recently...
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Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
RationaleCariprazine is an atypical antipsychotic that acts as a D3/D2 receptor partial agonist. In addition to treating positive symptoms of...
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Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses
Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). ECs...
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The Role of Dopamine D3 Receptors in Tobacco Use Disorder: A Synthesis of the Preclinical and Clinical Literature
Tobacco smoking is a significant cause of preventable morbidity and mortality globally. Current pharmacological approaches to treat tobacco use...
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Dopamine receptor D3 is related to prognosis in human hepatocellular carcinoma and inhibits tumor growth
BackgroundDopamine receptors have been reported to play important roles in cancer progression. However, the role of dopamine receptor D3 (DRD3) in...
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Treatment with 1,25-Dihydroxyvitamin D3 Delays Choroid Plexus Infiltration and BCSFB Injury in MRL/lpr Mice Coinciding with Activation of the PPARγ/NF-κB/TNF-α Pathway and Suppression of TGF-β/Smad Signaling
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of systemic lupus erythematosus (SLE) involving the nervous system...
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AMPK-mediated autophagy is involved in the protective effect of canagliflozin in the vitamin D3 plus nicotine calcification model in rats
Vascular calcification (VC) is a major risk factor for cardiovascular events. A mutual interplay between inflammation, oxidative stress, apoptosis,...
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How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors
Vascular P2Y receptors mediate many effects, but the role of individual subtypes is often unclear. Here we discuss how subtype-selective antagonists...
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Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action
The dopaminergic (DA) system regulates both motor function, and learning and memory. The cerebellum supports motor control and the acquisition of...
