Search
Search Results
-
Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs
The role of the striatum in motor control is commonly assumed to be mediated by the two striatal efferent pathways characterized by striatal...
-
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called temporal association learning. The...
-
Differential Roles of the D1- and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat
Several preclinical and clinical studies indicate that exposure to acute stress may decrease pain perception and increases pain tolerance. This...
-
Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway
RationaleClinical studies have revealed that methamphetamine abuse increases risk for develo** Parkinson’s diseases. It is thus important to...
-
Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons
Elevated dopamine transmission in psychosis is assumed to unbalance striatal output through D1- and D2-receptor-expressing spiny-projection neurons...
-
Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
-
Pharmacodynamics of Cyclin D1 Degradation in Ovarian Cancer Xenografts with Repeated Oral SHetA2 Dosing
SHetA2 is a promising, orally active small molecule with anticancer properties that target heat shock proteins. In this study, we aimed to...
-
Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
L-DOPA-induced dyskinesia (LID) in Parkinson’s disease has been linked to oscillatory neuronal activities in the cortico-basal ganglia network. We...
-
The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats
There are general inhibitory effects of exo-cannabinoids on dopamine-mediated behaviors. Many studies suggested the interaction between cannabinoid...
-
-
Involvement of Hippocampal D1-Like Dopamine Receptors in the Inhibitory Effect of Cannabidiol on Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference
Cannabidiol (CBD) is a non-psychotomimetic compound with strong potential to decrease the psychostimulant’s rewarding effect with unclear receptors....
-
D3 Receptors and Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely affects sleep. It is characterized by an urge to move the legs that is often...
-
Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the...
-
Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to...
-
Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate
RationaleDopamine (DA) signaling through the D1 receptor has been shown to be integral to multiple aspects of cognition, including the core process...
-
Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action
The dopaminergic (DA) system regulates both motor function, and learning and memory. The cerebellum supports motor control and the acquisition of...
-
The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions
BackgroundExtensive local invasion of glioblastoma (GBM) cells within the central nervous system (CNS) is one factor that severely limits current...
-
The functional role of P2 purinergic receptors in the progression of gastric cancer
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cells and GC tissues and...
-
Progressive Degeneration and Adaptive Excitability in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons Exposed to HIV-1 Tat and Morphine
The striatum is especially vulnerable to HIV-1 infection, with medium spiny neurons (MSNs) exhibiting marked synaptodendritic damage that can be...
-
Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210
RationaleThe emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological...
