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Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase...
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Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action
The dopaminergic (DA) system regulates both motor function, and learning and memory. The cerebellum supports motor control and the acquisition of...
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Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called temporal association learning. The...
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Dopamine-induced astrocytic Ca2+ signaling in mPFC is mediated by MAO-B in young mice, but by dopamine receptors in adult mice
Dopamine (DA) plays a vital role in brain physiology and pathology such as learning and memory, motor control, neurological diseases, and psychiatric...
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Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stop**
D 2 -like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric...
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Blockade of the Dopamine D3 Receptor Attenuates Opioids-Induced Addictive Behaviours Associated with Inhibiting the Mesolimbic Dopamine System
Opioid use disorder (OUD) has become a considerable global public health challenge; however, potential medications for the management of OUD that are...
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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
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The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats
There are general inhibitory effects of exo-cannabinoids on dopamine-mediated behaviors. Many studies suggested the interaction between cannabinoid...
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Differential Roles of the D1- and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat
Several preclinical and clinical studies indicate that exposure to acute stress may decrease pain perception and increases pain tolerance. This...
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Cerebellar dopamine D2 receptors regulate social behaviors
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including...
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Significant Functional Differences Between Dopamine D4 Receptor Polymorphic Variants Upon Heteromerization with α1A Adrenoreceptors
The functional role of the dopamine D 4 receptor (D 4 R) and its main polymorphic variants has become more evident with the demonstration of heteromers...
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The Role of Dopamine in Training Automaticity
Habits and motor skills serve to automate routine behaviors, allowing the fast and fluid execution of complex tasks while reducing cognitive load....
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Dopamine D2/3 Receptor Availabilities in Striatal and Extrastriatal Regions of the Adult Human Brain: Comparison of Four Methods of Analysis
Values of binding potentials ( BP ND ) of dopamine D 2/3 receptors differ in different regions of the brain, but we do not know with certainty how much...
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Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study,...
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PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III
Dopamine neurons are essential for voluntary movement, reward learning, and motivation, and their dysfunction is closely linked to various...
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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs
The role of the striatum in motor control is commonly assumed to be mediated by the two striatal efferent pathways characterized by striatal...
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The Dynamics of Dopamine D2 Receptor-Expressing Striatal Neurons and the Downstream Circuit Underlying L-Dopa-Induced Dyskinesia in Rats
L-dopa (l-3,4-dihydroxyphenylalanine)-induced dyskinesia (LID) is a debilitating complication of dopamine replacement therapy for Parkinson’s...
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Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway
The effects of ultraviolet (UV) radiation on brain function have previously been investigated; however, the specific neurotransmitter-mediated...
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Dopamine Receptors in the Gastrointestinal Tract
Dopamine (DA) regulates physiological functions through dopamine receptors (DARs), including D1, D2, D3, D4, and D5. All of the five subtypes mediate...
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Repeated cocaine administration upregulates CB2 receptor expression in striatal medium-spiny neurons that express dopamine D1 receptors in mice
Cannabinoid CB 2 receptors (CB 2 R) are importantly involved in drug reward and addiction. However, the cellular mechanisms underlying CB 2 R action...
