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Direct Cytosolic Delivery of Proteins Using Lyophilized and Reconstituted Polymer-Protein Assemblies
PurposeCytosolic delivery of proteins accesses intracellular targets for chemotherapy and immunomodulation. Current delivery systems utilize...
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Crosstalk between endoplasmic reticulum and cytosolic unfolded protein response in tomato
Conditions that cause proteotoxicity like high temperature trigger the activation of unfolded protein response (UPR). The cytosolic (CPR) and...
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Establishment and Fractionation of Metastatic Axillary Lymph Node Cell Suspension for Determination of Protein Expression Levels of Nuclear cFOS and Cytosolic TGFβ1 from Breast Cancer Patients
BackgroundMetastatic Axillary Lymph Node (mALN) status is currently the most important prognostic factor in the management of primary breast cancer...
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Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
Double-stranded DNA (dsDNA) in the cytoplasm of eukaryotic cells is abnormal and typically indicates the presence of pathogens or mislocalized...
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Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
The circadian system is a conserved time-kee** machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and...
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Cytosolic Cadherin 4 promotes angiogenesis and metastasis in papillary thyroid cancer by suppressing the ubiquitination/degradation of β-catenin
BackgroundAlthough the long-term prognosis of papillary thyroid cancer (PTC) is favorable, distant metastasis significantly compromises the prognosis...
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Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair
Diabetic wound healing, including diabetic foot ulcer (DFU), is a serious complication of diabetes. Considering the complexity of DFU development,...
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Cytosolic Escape of Mitochondrial DNA Triggers cGAS-STING Pathway-Dependent Neuronal PANoptosis in Response to Intermittent Hypoxia
Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), characterized by neuronal cell death...
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β-lapachone-mediated WST1 Reduction as Indicator for the Cytosolic Redox Metabolism of Cultured Primary Astrocytes
Electron cycler-mediated extracellular reduction of the water-soluble tetrazolium salt 1 (WST1) is frequently used as tool for the determination of...
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Role of cytosolic and endoplasmic reticulum Ca2+ in pancreatic beta-cells: pros and cons
Pancreatic beta cells utilize Ca 2+ to secrete insulin in response to glucose. The glucose-dependent increase in cytosolic Ca 2+ concentration ([Ca 2+ ] C )...
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Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF-κB levels
Based on their high antioxidant capacity and noteworthy phytochemistry, Terminalia ferdinandiana fruit and leaves have attracted considerable recent...
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Measurement of Cytosolic Mitochondrial DNA After NLRP3 Inflammasome Activation
The NLRP3 inflammasome, a key component of the innate immune system that mediates caspase-1 activation, which in turn induces cleavage of the...
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Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc...
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the...
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Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes
Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These...
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Protein Markers in the Detection of Cancer
Proteins are very important for cell mechanisms such as cell growth, metabolic process, cell signaling, and cell motility. The proteomic studies...
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Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
BackgroundApolipoprotein E4 ( APOE4 ) is associated with a greater response to neuroinflammation and the risk of develo** late-onset Alzheimer’s...
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Cystathionine β Synthase (CBS 844ins68) and Cytosolic Serine Hydroxy-Methyltransferase (SHMT1) (C1420T) Gene Polymorphisms and the Risk of Breast Cancer in the Egyptian Population
Breast Cancer, BC, is the most frequent cancer among women. Death from BC is approximately 15% of all cancer deaths among women. BC risk factors are...
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Protein Structure and Modification of Aquaporins
Aquaporins (AQPs) allow water molecules and other small, neutral solutes to quickly pass through membrane. The protein structures of AQPs solved by...