Search
Search Results
-
Cell Culture and Slide Preparation for Cytogenetic Studies of Hematological Neoplasms
Hematological neoplasms are heterogeneous diseases with various subtypes, each with its unique genomic features. Cell culture and slide preparation...
-
Cytogenetic profile of 1791 adult acute myeloid leukemia in India
BackgroundCytogenetic analysis continues to have an important role in the management of acute myeloid leukemia (AML) because it is essential for...
-
Cytogenetic culture failure and its causes in hematological disorders; a single centre perspective
ObjectiveTo highlight the reasons of culture failure in bone marrow aspirate samples sent for Cytogenetic analysis and to identify the associated...
-
The Length of Telomeres and the Baseline Level of Cytogenetic Damage in Leukocytes of Lung Cancer Patients
AbstractDespite the great efforts of basic and clinical research on lung cancer (LC), the prevention and treatment of this type of cancer show still...
-
Buccal Micronucleus Cytome Assay for the Evaluation of Cytogenetic Status of Healthcare Professionals Contacting with Anti-Cancer Drugs
AbstractHealthcare professionals of chemotherapy departments are in a regular contact with anticancer drugs that have genotoxic properties. The...
-
Analysis of complex chromosomal rearrangements using a combination of current molecular cytogenetic techniques
BackgroundUsing combined fluorescence in situ hybridization (FISH) and high-throughput whole-genome sequencing (WGS) molecular cytogenetic...
-
Candidate genes for infertility: an in-silico study based on cytogenetic analysis
BackgroundThe cause of infertility remains unclear in a significant proportion of reproductive-age couples who fail to conceive naturally....
-
Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review
Indoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households....
-
Comprehensive analysis of early pregnancy loss based on cytogenetic findings from a tertiary referral center
BackgroundPregnancy loss is one of the most common complications during pregnancy. Clinical consultation based on etiology analysis are critical for...
-
Monitoring Very Low Dose Radiation Damage in DNA Using “Field-Friendly” Biomarkers
The retrospective assessment of radiation exposures using quantitative biomarkers related to dose is well established for the purpose of biological...
-
High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response
AbstractPrevious evidence has confirmed that branched-chain aminotransferase-1 ( BCAT1 ), a key enzyme governing branched-chain amino acid (BCAA)...
-
The Baseline Level of Cytogenetic Damage in Lymphocytes and Buccal Epitheliocytes of Lung Cancer Patients
The results of the study of chromosomal aberrations and micronuclei in blood lymphocytes, as well as micronuclei in buccal epithelium cells of 50...
-
DNA Damage in Splenocytes of Mice Exposed to Secondary Radiation Created by 650 MeV Protons Bombarding a Concrete Shielding Barrier
The proportion of splenocytes with a high level of DNA double-strand breaks was determined in mice exposed to primary and secondary radiation created...
-
Cytogenetic abnormalities in multiple myeloma: association with disease characteristics and treatment response
Cytogenetic abnormalities are found in most multiple myeloma (MM) patients. Although their prognostic value has been well studied, there are limited...
-
Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage
Neonicotinoids are the most widely used pesticides in the world. However, research studies have shown that it can affect the cognitive abilities and...
-
An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems
DNA damage is one of the most important effects induced by chemical agents. We report a comparative analysis of DNA fragmentation on three different...
-
Identification of Cyto- and Genotoxic Effects of Lunularic Acid in Allium cepa L. Root Tip Meristem Cells
AbstractIn this study, dose-dependent effects of lunularic acid (LA) on some physiological, cytogenetic, biochemical and anatomical parameters were...
-
Bovine Whole Blood Cells as a Biomarker Platform for Biological Toxicology: A Focus on Thiacloprid
In the present work, we deal with using bovine whole blood cells in cytotoxicity and genotoxicity studies of neonicotinoid insecticide thiacloprid...
-
The study of genotoxicity and immunotoxicity in workers occupationally exposed to cyanide
ObjectWorkers are exposed to a wide range of organic and inorganic pollutants during their work, which may cause them serious health damage related...
-
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes
Increasing exploration of rare-earth elements (REEs) has resulted in a high REEs’ exposure risk. Owing to their persistence and accumulation of REEs...
