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Diagnostic performance of circulating biomarkers for non-alcoholic steatohepatitis
There are no approved diagnostic biomarkers for at-risk non-alcoholic steatohepatitis (NASH), defined by the presence of NASH, high histological...
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Randomized phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer (NCT03093155): Updated survival and subgroup analyses
BackgroundIxabepilone may retain activity in paclitaxel-resistant disease. We previously reported improved response rates (ORR), progression-free...
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Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial
BackgroundSurgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard...
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A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial
BackgroundSome cancers such as sarcomas (bone and soft tissue sarcomas) and adenoid cystic carcinomas are considered as radioresistant to low linear...
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Comparison of Aerosol Deposition Between a Cynomolgus Macaque and a 3D Printed Cast Model of the Animal
PurposePreclinical aerosol studies using animals are essential for evaluating toxic or therapeutic effects on human respiratory tract.
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A prospective interventional study investigating sleep disorders prior to and during adjuvant radiotherapy for breast cancer
BackgroundMost breast cancer patients with non-metastatic disease receive adjuvant local or loco-regional radiotherapy. To be scheduled for...
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Axicabtagene ciloleucel as second-line therapy in large B cell lymphoma ineligible for autologous stem cell transplantation: a phase 2 trial
Axicabtagene ciloleucel (axi-cel) demonstrated superior efficacy compared to standard of care as second-line therapy in patients with high-risk...
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Locally advanced NSCLC: a plea for sparing the ipsilateral normal lung—prospective, clinical trial with DART-bid (dose-differentiated accelerated radiation therapy, 1.8 Gy twice daily) by VMAT
BackgroundIn radiation treatment of locally advanced non-small cell lung cancer (LA-NSCLC), ‘margins’ from internal target volumes to planning target...
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Randomised phase II trial of weekly ixabepilone ± biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer
BackgroundThis multi-center RP2 study assessed activity/safety of ixabepilone + bevacizumab compared to ixabepilone in platinum-resistant/refractory...
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The impact of age on rectal cancer treatment, complications and survival
BackgroundThe number of older patients with rectal cancer is increasing. Treatment outcome discrepancies persist, despite similar treatment...
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Differential PD-1/LAG-3 expression and immune phenotypes in metastatic sites of breast cancer
BackgroundA dual blockade against the novel immune checkpoint inhibitor lymphocyte activation gene-3 (LAG-3) and programmed cell death protein-1...
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Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and...
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Spectrum and prevalence of BRCA1/2 germline mutations in Pakistani breast cancer patients: results from a large comprehensive study
BackgroundPathogenic germline mutations in BRCA1 and BRCA2 ( BRCA1/2 ) account for the majority of hereditary breast and/or ovarian cancers worldwide....
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Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients
BackgroundPathogenic germline variants in MLH1 , MSH2 and MSH6 genes account for the majority of Lynch syndrome (LS). In this first report from...
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The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
Carbohydrates — namely glycans — decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics and tools...
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Association between serum levels of caspase-cleaved cytokeratin-18 and early mortality in patients with severe spontaneous intracerebral hemorrhage
BackgroundApoptotic changes after cerebral hemorrhage in brain samples of humans have been found. Caspase-cleaved cytokeratin (CCCK)-18 could be...
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An open-label, randomized, phase II trial evaluating the efficacy and safety of standard of care with or without bevacizumab in platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer patients previously treated with bevacizumab for front-line or platinum-sensitive ovarian cancer: rationale, design, and methods of the Japanese Gynecologic Oncology Group study JGOG3023
BackgroundWe present the study rationale and design of the JGOG3023 study, an open-label, parallel-arm, randomized, phase II trial that aimed to...
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Respiration-related cerebral blood flow variability increases during control-mode non-invasive ventilation in normovolemia and hypovolemia
PurposeIncreased variability in cerebral blood flow (CBF) predisposes to adverse cerebrovascular events. Oscillations in arterial blood pressure and...
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Magnetic Resonance Morphometry of Neuroplastic Changes in the Brain during Conservative Treatment of Traumatic Brachial Plexopathy
Objectives. To identify neuroplastic changes in brain structures in the treatment of traumatic axonotomy of the brachial plexus using MR morphometry...