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D-Ribose-L-Cysteine and L-Dopa Co-Supplementation Attenuates Paraquat-Induced Oxidative Damage and Locomotion Deficit in Drosophila melanogaster
AbstractD-ribose L-cysteine is a glutathione precursor that acts as an antioxidant. In the present study, we investigated the effect of D-ribose...
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Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells
Acetaminophen (APAP) belong among the most used analgesics and antipyretics. It is structurally derived from p -aminophenol (PAP), a potent inducer of...
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The role of rhoA/rho-kinase and PKC in the inhibitory effect of L-cysteine/H2S pathway on the carbachol-mediated contraction of mouse bladder smooth muscle
We investigated the role of RhoA/Rho-kinase (ROCK) and PKC in the inhibitory effect of L-cysteine/hydrogen sulfide (H 2 S) pathway on the...
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Niosomes loading N-acetyl-L-cysteine for cancer treatment in vivo study
Scientists are seeking to find an effective treatment for tumors that has no side effects. N-Acetyl-l-cysteine (NAC) is a thiol compound extracted...
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Design, synthesis, and biological studies of the new cysteine-N-arylacetamide derivatives as a potent urease inhibitor
Inhibition of Helicobacter pylori urease is an effective method in the treatment of several gastrointestinal diseases in humans. This bacterium plays...
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Free–L-Cysteine improves corticosterone-induced behavioral deficits, oxidative stress and neurotransmission in rats
L-Cysteine (L-Cys) is a semi-essential amino acid. It serves as a substrate for enzyme cystathionine-β-synthase in the central nervous system (CNS)....
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D-ribose-L-cysteine exhibits restorative neurobehavioral functions through modulation of neurochemical activities and inhibition oxido-inflammatory perturbations in rats exposed to polychlorinated biphenyl
Polychlorinated biphenyl (PCB) is potentially harmful environmental toxicant causing cognitive decline with depressive features. PCB-induced...
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On-Off-On Fluorometric Detection of Hg(II) and L-Cysteine Using Red Emissive Nitrogen-Doped Carbon Dots for Environmental and Clinical Sample Analysis
This research introduces a novel fluorescence sensor ‘on-off-on’ employing nitrogen-doped carbon dots (N-CDs) with an ‘on-off-on’ mechanism for the...
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Cysteine Metabolism in Cancer Progression and Therapy Resistance
Redox homeostasis and sustainable energy production are vital for cancer survival and growth. As cancer cells proliferate uncontrollably, metabolic...
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Immunohistochemical localisation of vasopressin/oxytocin-type, corazonin-type and luqin-type neuropeptide expression in the starfish Asterias rubens using antibodies to the C-terminal region of precursor proteins
Neuropeptides derived from larger precursor proteins are secreted as signalling molecules by neurons and regulate diverse physiological and...
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The Effect of Prenatal Hypoxia on the Metabolism of Amyloid Precursor Protein
Abstract —The constitutive transmembrane amyloid precursor protein (APP) is not only one of the factors contributing to the pathogenesis of...
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Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations
The extent to which neurogenesis occurs in adult primates remains controversial. In this study, using an optimized single-cell RNA sequencing...
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The amyloid precursor protein: a converging point in Alzheimer’s disease
The decades of evidence that showcase the role of amyloid precursor protein (APP), and its fragment amyloidβ (Aβ), in Alzheimer’s disease (AD)...
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Cysteine metabolic circuitries: druggable targets in cancer
To enable survival in adverse conditions, cancer cells undergo global metabolic adaptations. The amino acid cysteine actively contributes to cancer...
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Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express...
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The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein with pleiotropic functions, which is expressed in...
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Horizontally acquired cysteine synthase genes undergo functional divergence in lepidopteran herbivores
Horizontal gene transfer (HGT) plays an important role in evolutionary processes as organisms adapt to their environments, and now cases of gene...
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Caffey disease is associated with distinct arginine to cysteine substitutions in the proα1(I) chain of type I procollagen
PurposeInfantile Caffey disease is a rare disorder characterized by acute inflammation with subperiosteal new bone formation, associated with fever,...
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Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities
Nanostructured fluorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The...
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A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4–ROS–NLRP3 pathway
BackgroundGiant pandas ( Ailuropoda melanoleuca ) are the obligate host of the parasitic roundworm Baylisascaris schroederi . The infection of giant...
