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Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism
Pheochromocytomas and paragangliomas (PPGLs) cause symptoms by altering the circulation levels of catecholamines and peptide hormones. Currently, the...
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Cysteine-cysteine Chemokine Receptor Type 5 Plays a Critical Role in Exercise Performance by Regulating Mitochondrial Content in Skeletal Muscle
Cysteine-cysteine chemokine receptor type 5 (CCR5) is thought to play an important role in the trafficking of lymphoid cells but has recently also...
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Cysteine Metabolism in Cancer Progression and Therapy Resistance
Redox homeostasis and sustainable energy production are vital for cancer survival and growth. As cancer cells proliferate uncontrollably, metabolic...
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Cysteine Homeostasis Disturbance in Escherichia coli Caused by Exposure to Ciprofloxacin
E. coli exposure to ciprofloxacin disturbs cysteine homeostasis; an increase in the intracellular concentration of cysteine is dangerous due to its...
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Drug Metabolism
Living systems have developed elimination mechanisms to dispose of waste products and protect themselves from exposure to potentially harmful...
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Metabolism of Vascular Smooth Muscle
Metabolism refers to chemical reactions that take place in an organism to maintain its structure and activities, to respond to environment changes,...
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Design, synthesis, and biological studies of the new cysteine-N-arylacetamide derivatives as a potent urease inhibitor
Inhibition of Helicobacter pylori urease is an effective method in the treatment of several gastrointestinal diseases in humans. This bacterium plays...
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Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells
Acetaminophen (APAP) belong among the most used analgesics and antipyretics. It is structurally derived from p -aminophenol (PAP), a potent inducer of...
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D-Ribose-L-Cysteine and L-Dopa Co-Supplementation Attenuates Paraquat-Induced Oxidative Damage and Locomotion Deficit in Drosophila melanogaster
AbstractD-ribose L-cysteine is a glutathione precursor that acts as an antioxidant. In the present study, we investigated the effect of D-ribose...
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Niosomes loading N-acetyl-L-cysteine for cancer treatment in vivo study
Scientists are seeking to find an effective treatment for tumors that has no side effects. N-Acetyl-l-cysteine (NAC) is a thiol compound extracted...
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Homocysteine and Folic Acid Metabolism
Homocysteine (Hcy) and folate metabolism plays a crucial role in maintaining the overall human health. Hcy is a non-proteinogenic amino acid...
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Metabolism of Cancer Stem Cell
Nowadays, cancer is considered as a stem cell disease of altered metabolism. The metabolism of cancer stem cells (CSCs) is less well characterized...
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Serine metabolism in macrophage polarization
ObjectiveEmerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their...
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Metabolism in Hematopoiesis and Its Malignancy
Hematopoietic stem cells (HSCs) are multipotent stem cells that can self-renew and generate all blood cells of different lineages. The system is...
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Prognosis prediction based on methionine metabolism genes signature in gliomas
BackgroundGlioma cells have increased intake and metabolism of methionine, which can be monitored with 11 C-L-methionine. However, a short half-life...
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Abnormal Porphyrin Metabolism in Autism Spectrum Disorder and Therapeutic Implications
Autism spectrum disorder (ASD) is a mosaic of neurodevelopmental conditions composed of early-onset social interaction and communication deficits,...
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Anti-inflammatory peptide therapeutics and the role of sulphur containing amino acids (cysteine and methionine) in inflammation suppression: A review
BackgroundInflammation serves as our body’s immune response to combat infections, pathogens, viruses, and external stimuli. Inflammation can be...
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Targeting glutamine metabolism as a therapeutic strategy for cancer
Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids...
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The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein with pleiotropic functions, which is expressed in...
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Ferroptosis and cuproptposis in kidney Diseases: dysfunction of cell metabolism
Metal ions play an important role in living organisms and are involved in essential physiological activities. However, the overload state of ions can...
