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Development and validation of reassigned CEA, CYFRA21-1 and NSE-based models for lung cancer diagnosis and prognosis prediction
BackgroundThe majority of lung cancer(LC) patients are diagnosed at advanced stage with a poor prognosis. However, there is still no ideal diagnostic...
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Baseline serum tumor markers predict the survival of patients with advanced non-small cell lung cancer receiving first-line immunotherapy: a multicenter retrospective study
BackgroundThis study aimed to investigate the association between baseline serum tumor markers (STMs) (carcinoembryonic antigen [CEA],...
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Prognostic value of CYFRA 21 − 1 and Ki67 in advanced NSCLC patients with wild-type EGFR
BackgroundThe prognostic value of cytokeratin 19 fragment (CYFRA 21 − 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with...
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A preliminary study on the reference intervals of serum tumor marker in apparently healthy elderly population in southwestern China using real-world data
BackgroundThe aim is to establish and verify reference intervals (RIs) for serum tumor markers for an apparently healthy elderly population in...
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Evaluating the comprehensive diagnosis efficiency of lung cancer, including measurement of SHOX2 and RASSF1A gene methylation
Methylation of the promoters of SHOX2 and RASSF1A (LungMe®) exhibits promise as a potential molecular biomarker for diagnosing lung cancer. This...
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The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer (NSCLC) patients
BackgroundCEA, CYFRA21-1 and NSE are tumor markers used for monitoring the response to chemotherapy in advanced adenocarcinoma, squamous cell...
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Early detection of colorectal neoplasia: application of a blood-based serological protein test on subjects undergoing population-based screening
BackgroundBlood-based biomarkers used for colorectal cancer screening need to be developed and validated in appropriate screening populations. We...
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Diagnostic value of circulating genetically abnormal cells to support computed tomography for benign and malignant pulmonary nodules
BackgroundThe accuracy of CT and tumour markers in screening lung cancer needs to be improved. Computer-aided diagnosis has been reported to...
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Serum lncRNA THRIL predicts benign and malignant pulmonary nodules and promotes the progression of pulmonary malignancies
BackgroundThis project aimed to research the significance of THRIL in the diagnosis of benign and malignant solitary pulmonary nodules (SPNs) and to...
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Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers
The detection of biomarkers in blood macrophages is a new non-invasive cancer screening method, but its performance in early stage lung cancer...
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Integrated models of blood protein and metabolite enhance the diagnostic accuracy for Non-Small Cell Lung Cancer
BackgroundFor early screening and diagnosis of non-small cell lung cancer (NSCLC), a robust model based on plasma proteomics and metabolomics is...
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Exosome-transported circ_0061407 and circ_0008103 play a tumour-repressive role and show diagnostic value in non-small-cell lung cancer
BackgroundCircular RNAs (circRNAs), one of the major contents of exosomes, have been shown to participate in the occurrence and progression of...
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The diagnostic potential of a circRNA–miRNA network in non-small cell lung cancer
AbstractIncreasing studies demonstrate the significant contributions of circRNA-related competitive endogenous RNA (ceRNA) regulatory networks to...
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Plasma hepatocyte growth factor as a noninvasive biomarker in small cell lung cancer
BackgroundHepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine, which is overexpressed and/or activated in multiple...
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Bronchoalveolar Lavage Fluid Microbiota is Associated with the Diagnosis and Prognosis Evaluation of Lung Cancer
The gut microbiota and cancer have been demonstrated to be closely related. However, few studies have explored the bronchoalveolar lavage fluid...
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The value of haematological parameters and serum tumour markers for predicting KRAS mutations in 784 Chinese colorectal cancer patients: a retrospective analysis
BackgroundIdentifying the mutation status of KRAS is important for optimizing treatment in patients with colorectal cancer (CRC). The aim of this...
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Spectral CT-based radiomics signature for distinguishing malignant pulmonary nodules from benign
ObjectivesTo evaluate the discriminatory capability of spectral CT-based radiomics to distinguish benign from malignant solitary pulmonary solid...
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The role of adenocarcinoma subtypes and immunohistochemistry in predicting lymph node metastasis in early invasive lung adenocarcinoma
BackgroundIdentifying lymph node metastasis areas during surgery for early invasive lung adenocarcinoma remains challenging. The aim of this study...
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Cognitive changes are associated with increased blood-brain barrier leakage in non-brain metastases lung cancer patients
To explore the relationship between cognitive function and blood–brain barrier leakage in non-brain metastasis lung cancer and healthy controls. 75...
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Applications of Nanotechnology in Pulmonary Disease Diagnosis
Nanotechnology is one of the highest priority research areas in medicine and a potentially useful tool for the diagnosis and treatment of pulmonary...