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Biomedicine

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Showing 1-20 of 3,254 results

  1. Pharmacokinetic Parameters of Recombinant Human Cyclophilin A in Mice

    Background and Objective

    Cyclophilin A (CypA) is an isomerase that functions as a chaperone, housekee** protein, and cyclosporine A (CsA) ligand....

    Anastasiia Kalinina, Elena Grigorieva, ... Ludmila Khromykh in European Journal of Drug Metabolism and Pharmacokinetics
    Article 01 December 2023

  2. CD147 and cyclophilin A: a promising potential targeted therapy for COVID-19 and associated cancer progression and chemo-resistance

    Coronavirus disease-2019 (COVID-19), as a worldwide serious issue has been shown to lead to progression and poor outcomes in cancer patients. The...

    Maryam Bakhtiyari, Ayda Haji Aghasi, ... Hamidreza Zalpoor in Infectious Agents and Cancer
    Article Open access 04 April 2023

  3. Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice

    Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a...

    Bijay Kumar Jha, Sanjay Varikuti, ... Bradford S. McGwire in npj Vaccines
    Article Open access 25 April 2023

  4. Cyclophilin A: a possible host modulator in Chandipura virus infection

    Chandipura virus (CHPV), belonging to the genus Vesiculovirus of the family Rhabdoviridae , has been identified as one of the causes of pediatric...

    Daya V. Pavitrakar, Nitin M. Atre, ... Pratip Shil in Archives of Virology
    Article 17 September 2021

  7. Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study

    Background

    Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an...

    Sharon Bright Amanya, Brian Nyiro, ... Obondo J. Sande in Retrovirology
    Article Open access 06 July 2020

  8. Prognostic Significance of Tumor-Associated Inflammation in Renal Cell Carcinoma

    This study analyzed tumor-associated inflammation by assessing the expression of cyclophilin A (CypA) and TNF in samples of kidney tumors of various...

    O. V. Kovaleva, P. A. Podlesnaya, ... A. N. Gratchev in Bulletin of Experimental Biology and Medicine
    Article 01 January 2024

  9. Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease

    The nucleus-encoded 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) regulates cyclophilin D (cypD) in the mitochondrial matrix. CypD regulates...

    Zdenka Kristofikova, Tomas Springer, ... Jiri Homola in Neurochemical Research
    Article Open access 29 January 2020

  10. Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

    Background

    Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived...

    Kouminin Kanwore, Konimpo Kanwore, ... DianShuai Gao in Inflammation and Regeneration
    Article Open access 13 October 2023

  11. Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage

    Objective

    The potential roles and mechanisms of pericytes in maintaining blood–brain barrier (BBB) integrity, which would be helpful for the...

    Pengyu Pan, Hengli Zhao, ... Yujie Chen in Journal of Neuroinflammation
    Article Open access 11 January 2020

  12. Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis

    Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss...

    Milton Guilherme Forestieri Fernandes, Abdulshakour Mohammadnia, ... Jack P. Antel in Acta Neuropathologica Communications
    Article Open access 05 July 2023

  13. Current understanding on molecular drug targets and emerging treatment strategy for novel coronavirus-19

    SARS-CoV-2 is an enveloped positive-sense RNA virus, contain crown-like spikes on its surface, exceptional of large RNA genome, and a special...

    Khadga Raj, Karamjeet Kaur, ... Shamsher Singh in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article 07 May 2021

  14. Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

    Background

    Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl...

    Wang Peng, Jiong Shi, ... Till Böcking in Retrovirology
    Article Open access 04 April 2019

  15. A Brief Insight into Peptide and Non-Peptide Drugs of Fungal Origin

    Microorganisms are valuable resources for obtaining bioactive compounds, which have proven to be very useful in various domains, e.g., agriculture,...
    A. Bhama Mishra, P. Usha, V. Sabareesh in Fungi Bioactive Metabolites
    Chapter 2024

  16. Structural and Functional Features of Ca2+ Transport Systems in Liver Mitochondria of Rats with Experimental Hyperthyroidism

    We analyzed structural and functional features of the main mitochondrial Ca 2+ -transporting systems, mitochondrial Ca 2+ uniporter complex (MCUC) and Ca

    N. V. Belosludtseva, E. Yu. Talanov, ... K. N. Belosludtsev in Bulletin of Experimental Biology and Medicine
    Article 01 June 2020

  17. Protective effects of pyrroloquinoline quinone in brain folate deficiency

    Background

    Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate...

    Vishal Sangha, Sara Aboulhassane, ... Reina Bendayan in Fluids and Barriers of the CNS
    Article Open access 20 November 2023

  18. Anti-proliferative activity of RIHMS-Qi-23 against MCF-7 breast cancer cell line is through inhibition of cell proliferation and senescence but not inhibition of targeted kinases

    Background

    Breast cancer is the most common malignancy globally, and is considered a major cause of cancer-related death. Tremendous effort is exerted...

    Randa El-Gamal, Sara Elfarrash, ... Mohammed I. El-Gamal in BMC Cancer
    Article Open access 02 November 2023

  19. Cyclophilin

    Suchismita Roy, Prabhjeet Singh, ... Ashwani Pareek in Encyclopedia of Signaling Molecules
    Reference work entry 2018

  20. Connective Tissue Disorders in Domestic Animals

    Though soft tissue disorders have been recognized and described to some detail in several types of domestic animals and small mammals for some years,...
    Jennifer Hope Roberts, Jaroslava Halper in Progress in Heritable Soft Connective Tissue Diseases
    Chapter 2021
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