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Polysaccharide isolated from wax apple suppresses ethyl carbamate-induced oxidative damage in human hepatocytes
Wax apple ( Syzygium samarangense ) has received growing research interest for its high nutritional and medicinal value due to its constituents such as...
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Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes
Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants with various adverse health effects in humans including disruption of lipid...
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Sex-dependent dynamics of metabolism in primary mouse hepatocytes
The liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic,...
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Enhanced activation of human NK cells by drug-exposed hepatocytes
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new...
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In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes
The use of micro-patterned co-cultured hepatocytes for human hepatic clearance predictions has previously been demonstrated using drugs metabolized...
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Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes
Transcriptomics is develo** into an invaluable tool in toxicology. The aim of this study was, using a transcriptomics approach, to identify genes...
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Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy
Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with...
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Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity
Hepatitis B virus (HBV) infection is a noteworthy cause of liver diseases, especially cirrhosis and hepatocellular carcinomas. However, the...
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Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC–MS-based untargeted metabolomics
Despite the high prevalence of alcoholic liver disease, its identification and characterization remain poor, especially in early stages such as...
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In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system
Liver fibrosis is the late consequence of chronic liver inflammation which could eventually lead to cirrhosis, and liver failure. Among various...
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Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling
BackgroundHepatic ischemia–reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT)....
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Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis
Mitochondrial DNA (mtDNA) released through protein oligomers, such as voltage-dependent anion channel 1 (VDAC1), triggers innate immune activation...
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Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations
The HepaRG cell line represents a successful model for hepatotoxicity studies. These cells are of human origin and are differentiated in vitro into...
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Distribution: Across Barriers
Distribution of drugs across barriers plays a predominant role in the processes of absorption (A), distribution (D), and excretion (E) and is thus a...
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Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes
Primary human hepatocytes (PHHs) remain the gold standard for in vitro testing in the field of pharmacology and toxicology. One crucial parameter...
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Benzoyl-CoA conjugate accumulation as an initiating event for male reprotoxic effects in the rat? Structure–activity analysis, species specificity, and in vivo relevance
A number of para -substituted benzoic acids ( p -BA) and chemicals metabolized to p -BA have been found to confer adverse effects in male rats on sperm...
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Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment
Cancer is ranked as the deadliest prime health issue, albeit with mammoth efforts to panacea the ailment. To subdue the vast constraints in tumor...
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Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters
BackgroundInhalation of lead oxide nanoparticles (PbO NPs), which are emitted to the environment by high-temperature technological processes, heavily...
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Research progress and application of liver organoids for disease modeling and regenerative therapy
The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual incidence of liver disease...
