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Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Gliomas are the most common primary tumors of the central nervous system, with approximately half of patients presenting with the most aggressive...
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A Case Study for Critical Reagent Qualification for Ligand Binding Assays Using Equivalence Test Methodology
Qualifying critical reagents in ligand binding assays by parallel testing of current and candidate reagent lots is recommended by regulatory agencies...
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A critical review of critical power
The elegant concept of a hyperbolic relationship between power, velocity, or torque and time to exhaustion has rightfully captivated the imagination...
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Local signal variability and functional connectivity: Sensitive measures of the excitation-inhibition ratio?
A novel network version of permutation entropy, the inverted joint permutation entropy (JPE inv ), holds potential as non-invasive biomarker of...
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Glucose Variability Measures in Critical Care
Hyperglycemia commonly occurs in critically ill patients. Research over the past 20 years has evolved to indicate that glucose variability – not...
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Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study
Myelination of human brain white matter (WM) continues into adulthood following birth, facilitating connection within and between brain networks. In...
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Plasma Markers of Cholestasis in Critical Illness
Cholestasis occurs often in critically ill for multiple reasons, whereas different mechanisms are not completely understood and a definition not...
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Deciphering the omicron variant: integrated omics analysis reveals critical biomarkers and pathophysiological pathways
BackgroundThe rapid emergence and global dissemination of the Omicron variant of SARS-CoV-2 have posed formidable challenges in public health. This...
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Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19
Several genetic and immunological risk factors for severe COVID-19 have been identified, with monogenic conditions relating to 13 genes of type I...
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The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression
BackgroundEffort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have immunomodulatory properties...
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ThPOK is a critical multifaceted regulator of myeloid lineage development
The transcription factor ThPOK (encoded by Zbtb7b ) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we...
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Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Critically ill patients in intensive care units experience profound alterations of their gut microbiota that have been linked to a high risk of...
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D-Dimer Levels, Stroke, and Critical Care
Biomarkers are important tools in medical decision-making. D-Dimer levels show diagnostic and promising prognostic implications in several diseases...
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Measuring critical force in sport climbers: a validation study of the 4 min all-out test on finger flexors
PurposeThe critical force (CF) concept, differentiating steady and non-steady state conditions, extends the critical power paradigm for sport...
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Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy
BackgroundPlatelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study,...
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CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex
The identification of key regulatory factors that control osteoclastogenesis is important. Accumulating evidence indicates that circular RNAs...
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The association between neutrophil-to-lymphocyte ratio and disease activity in rheumatoid arthritis
The inflammatory response is responsible for the promotion of pannus development over the joint, which is the primary factor in joint injury in...
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Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
BackgroundNeutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressive increase of...
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Prevalence of Neutralizing Autoantibodies Against Type I Interferon in a Multicenter Cohort of Severe or Critical COVID-19 Cases in Shanghai
ObjectiveWe sought to explore the prevalence of type I interferon-neutralizing antibodies in a Chinese cohort and its clinical implications during...
