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CpG island status as an epigenetic alteration for NIS promoter in thyroid neoplasms; a cross-sectional study with a systematic review
BackgroundGene silence via methylation of the CpG islands is cancer's most common epigenetic modification. Given the highly significant role of NIS ...
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The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis
BackgroundThe ESR 1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in...
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The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer
BackgroundHigh-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its...
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Maternal obesity alters methylation level of cytosine in CpG island for epigenetic inheritance in fetal umbilical cord blood
BackgroundOver the past few decades, global maternal obesity prevalence has rapidly increased. This condition may induce long-lasting...
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Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease
BackgroundE-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with susceptibility to Crohn...
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Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population
BackgroundWhile multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose,...
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Epigenome-Wide Association Study of CpG Methylation in Aggressive Behavior
AbstractThe DNA methylation profile can reflect both genetic features and exposure to the external factors that affect certain human traits,...
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DOK7 CpG hypermethylation in blood leukocytes as an epigenetic biomarker for acquired tamoxifen resistant in breast cancer
BackgroundBreast cancer (BC) is among the most common cause of cancer 10.4% and one of the leading causes of death among 20–50 years old women in the...
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Association between risk factors, molecular features and CpG island methylator phenotype colorectal cancer among different age groups in a Taiwanese cohort
BackgroundCpG island methylator phenotype (CIMP) represents a carcinogenesis pathway of colorectal cancer (CRC) and the association between CIMP CRC,...
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Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa
BackgroundCpG methylation of tumor suppressor genes occurs in the early stage of carcinogenesis. Detecting risk factors for aberrant CpG methylation...
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Phospholipase C delta 1 inhibits WNT/β‐catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma
BackgroundPLCD1 , located at 3p22, encodes an enzyme that mediates cellular metabolism and homeostasis, intracellular signal transduction and...
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Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
MECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders...
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The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)—Implications for Parkinson’s Disease and Rett Syndrome
Mounting evidence suggests a prominent role for alpha-synuclein (a-syn) in neuronal cell function. Alterations in the levels of cellular a-syn have...
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A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources
BackgroundMyeloid-derived suppressor cells (MDSCs), which include monocytic (mMDSCs) and granulocytic (gMDSCs) cells, are an immunosuppressive,...
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Screening the genome for HCC-specific CpG methylation signatures as biomarkers for diagnosis and prognosis evaluation
BackgroundHepatocellular carcinoma (HCC) is one of the most common and invasive malignant tumors in the world. The change in DNA methylation is a key...
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The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents
MGMT -promoter methylation is associated with favorable outcome in glioblastoma. The aim of this study was to determine whether the absolute number of...
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Methyl CpG binding protein MBD2 has a regulatory role on the BRCA1 gene expression and its modulation by resveratrol in ER+, PR+ & triple-negative breast cancer cells
BackgroundResveratrol has demonstrated its ability to regulate BRCA1 gene expression in breast cancer cells, and previous studies have established...
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Analysis of Il36a induction by C/EBPβ via a half-CRE•C/EBP element in murine macrophages in dependence of its CpG methylation level
Interleukin-36α is a novel member of the IL-1 cytokine family that is highly expressed in epithelial tissues and several myeloid-derived cell types...
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Marsupials have monoallelic MEST expression with a conserved antisense lncRNA but MEST is not imprinted
The imprinted isoform of the Mest gene in mice is involved in key mammalian traits such as placental and fetal growth, maternal care and mammary...
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Comparative analysis of CpG islands in equine infectious anemia virus strains
Increasing evidence suggests that DNA methylation has key roles in the replication of retroviruses, including lentiviruses, and pathogenesis of...
