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Retinal nerve fibre layer thinning and corneal nerve loss in patients with Bardet-Biedl syndrome
BackgroundBardet-Biedl syndrome (BBS) is an autosomal recessive, genetically heterogeneous, pleiotropic disorder caused by variants in genes involved...
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Progranulin Facilitates Corneal Repair Through Dual Mechanisms of Inflammation Suppression and Regeneration Promotion
The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and damage that can disrupt corneal epithelium and...
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Deep learning prediction of steep and flat corneal curvature using fundus photography in post-COVID telemedicine era
Recently, fundus photography (FP) is being increasingly used. Corneal curvature is an essential factor in refractive errors and is associated with...
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Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review
Healthy cornea guarantees the refractive power of the eye and the protection of the inner components, but injury, trauma or pathology may impair the...
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Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2–IL-6 axis
BackgroundMounting evidence suggests that the immune system plays detrimental or protective roles in nerve injury and repair.
Main body ...
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DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway
Dry eye disease (DED) is a prevalent ocular disorder with a multifactorial etiology. The pre-angiogenic and pre-inflammatory milieu of the ocular...
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Increased activity of lacrimal gland mast cells are associated with corneal epitheliopathy in aged mice
The lacrimal gland undergoes significant structural and functional deterioration with aging. Marked with increased inflammation and fibrosis, the...
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Comparison of In Vitro Corneal Permeation and In Vivo Ocular Bioavailability in Rabbits of Three Marketed Latanoprost Formulations
Background and ObjectiveAll latanoprost formulations currently available for the treatment of glaucoma or ocular hypertension contain the same...
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Wnt/β-catenin signaling stimulates the self-renewal of conjunctival stem cells and promotes corneal conjunctivalization
Limbal stem cell deficiency causes conjunctivalization characterized by the covering of the corneal surface with conjunctival epithelium. However,...
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Computational Model of In Vivo Corneal Pharmacokinetics and Pharmacodynamics of Topically Administered Ophthalmic Drug Products
IntroductionAlthough the eye is directly accessible on the surface of the human body, drug delivery can be extremely challenging due to the presence...
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Macular corneal dystrophy related to novel mutations of CHST6 in a Chinese family and clinical observation after penetrating keratoplasty
BackgroundMacular corneal dystrophy (MCD) is a rare corneal stromal dystrophy with bilateral progressive vision loss. The pathogenic gene of MCD is...
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Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding its distribution to posterior segments
PurposeTreating posterior segment diseases presents significant challenges because of the intricate anatomical and physiological barriers within the...
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Dependence of the heating effect on tissue absorption coefficient during corneal resha** using different UV lasers: A numerical study
Corneal resha** using laser ablation effect is a well-known ophthalmologic operation implemented to correct many vision disorders. UV pulsed lasers...
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Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution
Antibiotics are extremely useful, but they can cause adverse impacts on host bodies. We found that antibiotic treatment altered the composition of...
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Ocular topical application of alpha-glucosyl hesperidin as an active pharmaceutical excipient: in vitro and in vivo experimental evaluation
Alpha-glucosyl hesperidin (GH) is an aqueous soluble, amphipathic hesperidin derivative with several pharmacological effects, and it is postulated in...
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A human corneal ulcer caused by Thelazia callipaeda in Southwest China: case report
In this study, we describe a rare human case with corneal ulcer caused by thelaziosis in a 69-year-old man in Southwest China. A male nematode was...
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Aquaporins in Eye
The major part of the eye consists of water. Continuous movement of water and ions between the ocular compartments and to the systemic circulation is...
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Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent
Abstract3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed...
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Is bladder outlet obstruction rat model to induce overactive bladder (OAB) has similarity to human OAB? Research on the events in smooth muscle, collagen, interstitial cell and telocyte distribution
BackgroundCellular and cytoskeletal events of overactive bladder (OAB) have not been sufficiently explored in human bladder due to different...
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Fabrication and characterization of bilayer scaffolds made of decellularized dermis/nanofibrous collagen for healing of full-thickness wounds
Skin tissue engineering has progressed from simple wound dressings to biocompatible materials with desired physico-chemical properties that can...
