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Folic Acid–Chitosan Oligosaccharide Conjugates Decorated Nanodiamond as Potential Carriers for the Oral Delivery of Doxorubicin
Oral administration of doxorubicin (DOX) is preferred but challenged owing to poor permeability in the gastrointestinal tract (GIT), efflux of...
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Curcumin Modulates 1,2-dibehenoyl-sn-glycero-3-phosphocholine (DBPC) Liposomes: Chitosan Oligosaccharide Lactate Influences Membrane Fluidity But Does Not Alter Phase Transition Temperature of DBPC Liposomes
1,2-dibehenoyl-sn-glycero-3-phosphocholine (DBPC) is one of the important phospholipids found in cell membrane but not studied well. Importance of...
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The combination of serum oligosaccharide chain (G-test), alpha-fetoprotein, and aspartate aminotransferase to alanine aminotransferase ratio provides the optimal diagnostic value for early detection of hepatocellular carcinoma
BackgroundThe purpose of this study was to compare the diagnostic value of serum oligosaccharide chain (G-test), alpha-fetoprotein (AFP) and aspartic...
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Variants of a putative baseplate wedge protein extend the host range of Pseudomonas phage K8
BackgroundNarrow host range is a major limitation for phage applications, but phages can evolve expanded host range through adaptations in the...
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Mass spectrometric analysis of chondroitin sulfate-linked peptides
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components composed of linear glycosaminoglycan (GAG) side chains attached to a...
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A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles
Vaccines against infectious diseases should elicit potent and long-lasting immunity, ideally even in those with age-related decline in immune...
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Human Milk Oligosaccharide 2′-Fucosyllactose Reduces Neurodegeneration in Stroke Brain
2′-Fucosyllactose (2’-FL) is a major oligosaccharide in human milk and is present at trace levels in cow milk. 2’-FL reduces inflammation in the...
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Simultaneous analysis of serum α2,3-linked sialylation and core-type fucosylation of prostate-specific antigen for the detection of high-grade prostate cancer
BackgroundAltered prostate-specific antigen (PSA) glycosylation patterns can be useful biomarkers in detecting high-grade prostate cancer (HGPC). The...
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Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder
Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and behavior. Increasing...
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Development of semisynthetic saponin immunostimulants
Many natural saponins demonstrate immunostimulatory adjuvant activities, but they also have some inherent drawbacks that limit their clinical use. To...
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Lipopolysaccharide induced altered signaling pathways in various neurological disorders
Neuroinflammation is defined as an inflammatory response within the brain or spinal cord, whereas the brain’s innate immune system is triggered by...
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Substantial Basis for Glyco-Assembly: Siglec7 and Synthetic Sialylpolymers
Sialic acid is one of the tags that are recognized as “self,” when immune cells survey “non-self” items using the sialic acid-recognizing lectins,...
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Analytical Techniques to Study Carbohydrates
The description of a complex carbohydrate structure includes, in the first instance, monosaccharide composition, anomeric configurations, and the...
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Analysis of Carbohydrates by Mass Spectrometry
Mass spectrometry has become the favorite technique for glycomics analysis. This chapter describes the different ionization methods and provides...
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Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes – Then and Now
Cartilagescartilage are unique in the family of connective tissuesTissue in that they contain a high concentration of the...
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Carbohydrates: Binding Sites and Potential Drug Targets for Neural-Affecting Pathogens
A number of viruses that have caused wide spread concern e.g. Ebola, Zika, and SARS-CoV2 (severe acute respiratory syndrome coronavirus 2 also known...
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Importance and Monitoring of Therapeutic Immunoglobulin G Glycosylation
The complex diantennary-type oligosaccharides at Asn297 residues of the IgG heavy chains have a profound impact on the safety and efficacy of...
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Redox-Responsive and Electrically Neutral PLGA Nanoparticles for siRNA Delivery in Human Cervical Carcinoma Cells
PurposeMany non-viral vectors with positive charge and physical encapsulation of siRNA have been reported. However, the studies of non-viral vectors...
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Drosophila melanogaster MLE Helicase Functions Beyond Dosage Compensation: Molecular Nature and Pleiotropic Effect of mle[9] Mutation
AbstractMLE of D. melanogaster is a conserved protein in higher eukaryotes, an ortholog of human DHX9 helicase. In mammals, this helicase has been...
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Symbiogenetics and Symbiogenesis: The Molecular and Ecological Bases of Integrative Evolution
Symbiogenetics is presented as a discipline that studies the combined genetic systems that result from co-evolution of unrelated organisms. Their...
