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Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood
RationaleStress during childhood or adolescence increases vulnerability to psychiatric disorders in adults. In adult rodents, the delayed effects of...
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The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
RationaleRelapse into substance use is often triggered by exposure to drug-related environmental cues. The magnitude of drug seeking depends on the...
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CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice
Methamphetamine (Meth), a commonly used central nervous system stimulant, is highly addictive. Currently, there is no effective treatment for Meth...
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Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test
BackgroundCataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often...
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Assessment of Sexual Reward with the Conditioned Place Preference Paradigm
Sexual behavior, as other naturally motivated behaviors such as eating behavior, involves mesolimbic circuits that belong to the reward system as...
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Knockdown of Piccolo in the Nucleus Accumbens Suppresses Methamphetamine-Induced Hyperlocomotion and Conditioned Place Preference in Mice
Methamphetamine (METH), the most widely distributed psychostimulant, aberrantly activates the reward system in the brain to induce addictive...
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Reinstatement of nicotine conditioned place preference in a transgenerational model of drug abuse vulnerability in psychosis: Impact of BDNF on the saliency of drug associations
RationalePsychotic disorders such as schizophrenia are often accompanied by high rates of cigarette smoking, reduced quit success, and high relapse...
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Effects of imidazoline agents in a rat conditioned place preference model of addiction
Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The...
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Mechanisms underlying microRNA-222-3p modulation of methamphetamine-induced conditioned place preference in the nucleus accumbens in mice
RationaleMicroRNA (miRNA) control of post-transcription gene expression in the nucleus accumbens (NAc) has been implicated in methamphetamine (METH)...
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Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling
Drug-associated reward memories are conducive to intense craving and often trigger relapse. Simvastatin has been shown to regulate lipids that are...
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Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors
The number of cannabis users is increasing in the world. However, the mechanisms involved in the psychiatric effects and addiction formation remain...
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Expression of stable and reliable preference and aversion phenotypes following place conditioning with psychostimulants
Rationale and objectivesDrug-seeking behavior occurs more readily in some individuals than others. This phenomenon is considered in studies of drug...
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Compensatory Role of Insulin in the Extinction but Not Reinstatement of Morphine-Induced Conditioned Place Preference in the Streptozotocin-Induced Diabetic Rats
Insulin receptors are distributed in the whole brain, including different parts of the reward circuit that modulate dopamine as the primary...
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Inactivation of the thalamic paraventricular nucleus promotes place preference and sucrose seeking in male rats
RationaleThe experience of reward entails both positive affect and motivation. While the brain regions responsible for these distinct aspects of...
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MicroRNA-31-3p/RhoA signaling in the dorsal hippocampus modulates methamphetamine-induced conditioned place preference in mice
RationaleMicroRNAs (miRNAs) regulate neuroplasticity-related proteins and are implicated in methamphetamine (METH) addiction. RhoA is a small Rho...
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Effects of docosanyl ferulate, a constituent of Withania somnifera, on ethanol- and morphine-elicited conditioned place preference and ERK phosphorylation in the accumbens shell of CD1 mice
BackgroundDocosanyl ferulate (DF) is a behaviourally active GABA A receptor complex (GABA A R) agonist, recently isolated from the standardized...
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Vulnerability factors for mephedrone-induced conditioned place preference in rats—the impact of sex differences, social-conditioning and stress
RationaleMephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of...
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Adolescent cannabinoid exposure modulates the vulnerability to cocaine-induced conditioned place preference and DNMT3a expression in the prefrontal cortex in Swiss mice
RationaleCannabis sativa is the most widely used drug by adolescents globally. The recreational use of synthetic cannabinoids by teenagers has also...
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Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice
Cocaine addiction is a severe mental disorder for which few treatment options are available. The underlying mechanisms include facilitation of...
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Conditioned Place Preference Test for Assessing the Rewarding Effects of Drugs of Abuse
The conditioned place preference (CPP) procedure is used for assessing the rewarding effects of drugs. This is demonstrated when a novel environment...