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Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the...
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Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
BackgroundAlzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits...
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising...
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Causal Relationship Between Complement C3, C4, and Nonalcoholic Fatty Liver Disease: Bidirectional Mendelian Randomization Analysis
The complement system is activated during the development of nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the causal relationship...
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High serum complement component C4 as a unique predictor of unfavorable outcomes in diabetic stroke
Previous studies demonstrated that diabetic stroke patients had a poor prognosis and excess complement system activation in the peripheral blood. In...
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Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity and disease subgroups. The...
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A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins
To understand functional duality of the complement system in host defense and lung injury, a more comprehensive view of its localized production in...
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A guide to complement biology, pathology and therapeutic opportunity
Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has...
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Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models
The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few...
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Complement and Cancer Immunity
The complement system is a crucial mediator of the innate immune mechanisms; its three major activation pathways contribute to cellular homeostasis,...
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Increased infiltration of CD4+ T cell in the complement deficient lymphedema model
BackgroundLymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can...
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Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased expression of the complement component 4A ( C4A ). Yet, it...
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The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance
The complement system plays a dual role in the body, either as a first-line defense barrier when balanced between activation and inhibition or as a...
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The Role of Complement Regulatory Proteins During Liver Homeostasis and Hepatitis C Virus-Related Liver Disease
Hepatitis C virus (HCV) infection is often difficult to diagnose in its early stages. Throughout the infection, HCV demonstrably increases complement...
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Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer
BackgroundPrognosis of metastatic BRAF V600E mutant colorectal cancer (CRC) is poor, and the prognostic implications of immune contextures in the...
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Associations of cerebrospinal fluid complement proteins with Alzheimer’s pathology, cognition, and brain structure in non-dementia elderly
BackgroundCerebrospinal fluid (CSF) complement activation is a key part of neuroinflammation that occurs in the early stages of Alzheimer’s disease...
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XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner
BackgroundDifferences in male vs. female immune responses are well-documented and have significant clinical implications. While the immunomodulatory...
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Measures of Classical and Alternative Complement Function in Serum as Markers in Critical Care
The human complement system is a crucial component of the host response to pathogen invaders, cellular stress, and injury – all of which are common...
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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease
Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia...
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Complement Inhibition in Kidney Transplantation: Where Are We Now?
Kidney transplantation is a life-saving strategy for patients with end-stage renal disease. Although progress has been made in the field of...
