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A Systems Evaluation Model for the Development of Companion Diagnostics and Associated Molecularly Targeted Therapies
PurposeMonoclonal antibodies (mAbs) are important active ingredients of molecularly targeted drugs, which are only effective for specific patient...
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Cancer Diagnostics
Molecular diagnostic techniques supplement and increasingly replace traditional procedures. This chapter provides an overview and examples of...
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Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics
Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many cancer indications. This review provides an update on ICIs...
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Genetic medicine in companion diagnostics of germline BRCA testing of Japanese pancreatic cancer patients
In 2021, Japan’s national health insurance made germline BRCA (g. BRCA ) testing available to unresectable pancreatic cancer (PC) patients as a...
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Companion Diagnostics and Clinical Biomarkers for Immunotherapy
The advancement of understanding the complexity of disease biology unraveled many targets, and accordingly, their ligands are investigated. However,...
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Longitudinal study of ESBL/AmpC-producing Enterobacterales strains sharing between cohabiting healthy companion animals and humans in Portugal and in the United Kingdom
Extended-spectrum beta-lactamase (ESBL)- and plasmid-mediated cephalosporinase (AmpC)-producing Enterobacterales (ESBL/AmpC-E) are an increasing...
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New Breath Diagnostics for Fungal Disease
Purpose of ReviewDiagnosis of fungal disease etiology is often difficult, compounded by inaccurate or delayed diagnostic methods. Breath-based...
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How are we evaluating the cost-effectiveness of companion biomarkers for targeted cancer therapies? A systematic review
BackgroundDespite the increasing economic assessment of biomarker-guided therapies, no clear agreement exists whether existing methods are sufficient...
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Nationwide molecular survey of Dirofilaria immitis and Dirofilaria repens in companion dogs and cats, United States of America
BackgroundHeartworms, Dirofilaria immitis , are known to be widespread in dogs and cats in the USA, but there have been no country-wide prevalence...
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Point of Care Molecular Diagnostics in Cancer
Among the major challenges facing the clinical applications of point of care (PoC) devices is to enable rapid, accurate, convenient, and...
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Zoonotic and Multidrug-Resistant Bacteria in Companion Animals Challenge Infection Medicine and Biosecurity
At present, various zoonotic and multidrug resistant (MDR) bacteria, including but not limited to Staphylococcus aureus and Escherichia coli, are...
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AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology
The practice of medicine generates data in the management of patients to make decisions. Often health care providers rely on their problem-solving...
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CRISPR-based diagnostics
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic intervention and epidemiological surveillance. Diagnostics...
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A nationwide serological survey for Dirofilaria immitis in companion cats in the United States of America: 3.5% antibody and 0.3% antigen positivity
BackgroundFeline heartworm disease (HWD) is a complex and often misdiagnosed disease in cats, caused by the filarial nematode Dirofilaria immitis ....
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Point of Care Molecular Diagnostics in Cancer
Among the major challenges facing the clinical applications of point of care (PoC) devices is to enable rapid, accurate, convenient, and...
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Clinical implementation of RNA sequencing for Mendelian disease diagnostics
BackgroundLack of functional evidence hampers variant interpretation, leaving a large proportion of individuals with a suspected Mendelian disorder...
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An automated histological classification system for precision diagnostics of kidney allografts
For three decades, the international Banff classification has been the gold standard for kidney allograft rejection diagnosis, but this system has...
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Zoonotic and Multidrug-Resistant Bacteria in Companion Animals Challenge Infection Medicine and Biosecurity
At present, various zoonotic and multidrug resistant (MDR) bacteria, including but not limited to Staphylococcus aureus and Escherichia coli, are...
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Therapeutics and Diagnostics Discovery
In any therapeutics discovery and development effort, multiple critical steps must be accomplished to arrive at a compound that is safe and...