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Nutrition and Common Diseases

In this chapter, we will provide a first overview of the role of nutrition on our health and risk for disease. During the past 50 years a significant...

Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár in Molecular Medicine

Chapter 2023

RGS2 and female common diseases: a guard of women’s health

Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine...

Qiang Xu, Mukun Yao, Chao Tang in Journal of Translational Medicine

Article Open access 30 August 2023

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not...

Naomi Shek, Anna-Maria Choy, ... Jeffrey T. J. Huang in npj Aging

Article Open access 27 February 2024

Missed Opportunities to Diagnose Common Variable Immunodeficiency: a Population-Based Case–Control Study Identifying Indicator Diseases for Common Variable Immunodeficiency

Purpose

Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during...

Christina Dahl, Inge Petersen, ... Line D. Rasmussen in Journal of Clinical Immunology

Article Open access 28 September 2023

Inflammation as common link to progressive neurological diseases

Life expectancy has increased immensely over the past decades, bringing new challenges to the health systems as advanced age increases the...

Ana Dias-Carvalho, Susana Isabel Sá, ... Vera Marisa Costa in Archives of Toxicology

Article Open access 15 November 2023

“Mendelian Code” in the Genetic Structure of Common Multifactorial Diseases

Abstract

The phenomenon of comorbidity between monogenic and multifactorial diseases suggests the involvement of a certain common number of genes and...

M. S. Nazarenko, A. A. Sleptcov, V. P. Puzyrev in Russian Journal of Genetics

Article 11 October 2022

Perturbational phenoty** of human blood cells reveals genetically determined latent traits associated with subsets of common diseases

Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular...

Max Homilius, Wandi Zhu, ... Rahul C. Deo in Nature Genetics

Article Open access 04 December 2023

Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report

PRESTO was established in 2022 and is a concerted effort by leading European experts in the field of P2XRs and extracellular ATP to promote and...

Luke Tattersall, Elena Adinolfi, ... Ankita Agrawal in Purinergic Signalling

Article Open access 20 February 2024

Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases

Osteogenesis imperfecta type 10 (OI10) is caused by loss of function codon variants in the gene SERPINH1 that encodes heat shock protein 47 (HSP47),...

Alan Herbert in Genes & Immunity

Article 29 May 2024

Neuroprotective Effects of Bromelain on the Common Neurodegenerative Diseases: A Systematic Review

Abstract

In recent years, neurodegenerative diseases (NDs) have increased around the world and current treatments only provide temporary relief of the...

Sahar Rostamian, Elham Raeisi, ... Catherine M. T. Sherwin in Neurochemical Journal

Article 01 December 2023

Base Editing and Prime Editing: Potential Therapeutic Options for Rare and Common Diseases

Collectively, genetic disorders affect approximately 350 million individuals worldwide and are a major global health burden. Despite substantial...

Lauren C. Testa, Kiran Musunuru in BioDrugs

Article 14 June 2023

The causal relationship between COVID-19 and seventeen common digestive diseases: a two-sample, multivariable Mendelian randomization study

Objectives

In clinical practice, digestive symptoms such as nausea, vomiting are frequently observed in COVID-19 patients. However, the causal...

Zhiqi Wang, Huanyu Zhou, ... Haishan Huang in Human Genomics

Article Open access 26 September 2023

Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases

Multifactorial diseases are characterized by inter-individual variation in etiology, age of onset, and penetrance. These diseases tend to be...

Rachel J. Boyd, Dimitri Avramopoulos, ... Andrew S. McCallion in Journal of Neuroinflammation

Article Open access 08 September 2022

Rare diseases, common challenges

in Nature Genetics

Article 14 March 2022

Simultaneous prediction of risk for multiple common diseases using metabolomics

in Nature Medicine

Article 23 September 2022

Whole-genome risk prediction of common diseases in human preimplantation embryos

Preimplantation genetic testing (PGT) of in-vitro-fertilized embryos has been proposed as a method to reduce transmission of common disease; however,...

Akash Kumar, Kate Im, ... Matthew Rabinowitz in Nature Medicine

Article Open access 21 March 2022

GWAS to Identify SNPs Associated with Common Diseases and Individual Risk: Genome Wide Association Studies (GWAS) to Identify SNPs Associated with Common Diseases and Individual Risk

Association studies have enabled the exploration of alternative, more efficient methods for early detection, prevention and treatment of diseases by...

Gaya Hettiarachchi, Anton A. Komar in Single Nucleotide Polymorphisms

Chapter Open access 2022

Rare versus common diseases: a false dichotomy in precision medicine

Precision medicine initiatives are being launched worldwide, each with the capacity to sequence many thousands to millions of human genomes. At the...

Brian Hon Yin Chung, Jeffrey Fong Ting Chau, Gane Ka-Shu Wong in npj Genomic Medicine

Article Open access 24 February 2021