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The selective sponging of miRNAs by OIP5-AS1 regulates metabolic reprogramming of pyruvate in adenoma-carcinoma transition of human colorectal cancer
RNA interactomes and their diversified functionalities have recently benefited from critical methodological advances leading to a paradigm shift from...
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Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs
BackgroundBiomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas...
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Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma
BackgroundColorectal cancer (CRC), ranking third in cancer prevalence and second in mortality worldwide, is mainly derived from colorectal adenoma...
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Discovery of extracellular vesicle-delivered miR-185-5p in the plasma of patients as an indicator for advanced adenoma and colorectal cancer
BackgroundWe aimed to evaluate whether extracellular vesicles (EV)-derived microRNAs (miRNAs) can be used as biomarkers for advanced adenoma (AA) and...
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Serum untargeted lipidomics by UHPLC-ESI-HRMS aids the biomarker discovery of colorectal adenoma
BackgroundColorectal adenoma (CA) is an important precancerous lesion and early screening target of colorectal cancer (CRC). Lipids with numerous...
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Colorectal Cancer
Carcinomas of the colon and rectum (colorectal cancer, CRC) are among the most prevalent cancers worldwide. Colorectal cancers develop through a...
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Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps
BackgroundMost colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse...
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Association between pre-diagnostic circulating adipokines and colorectal cancer and adenoma in the CLUE II cohort
ObjectiveObesity is a known risk factor for colorectal cancer (CRC) and adenoma. Obese individuals have higher circulating concentrations of certain...
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Develo** an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies
BackgroundEarly detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals....
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Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma
BackgroundDeterioration of normal intestinal epithelial cells is crucial for colorectal tumorigenesis. However, the process of epithelial cell...
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Artificial intelligence for the prevention and prediction of colorectal neoplasms
BackgroundColonoscopy is a useful as a cancer screening test. However, in countries with limited medical resources, there are restrictions on the...
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Dairy intake during adolescence and risk of colorectal adenoma later in life
BackgroundHigher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several...
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Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients
BackgroundColibactin, a genotoxin produced by polyketide synthase harboring ( pks + ) bacteria, induces double-strand breaks and chromosome...
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5-Aminosalicylic acid inhibits stem cell function in human adenoma-derived cells: implications for chemoprophylaxis in colorectal tumorigenesis
BackgroundMost colorectal cancers (CRC) arise sporadically from precursor lesions: colonic polyps. Polyp resection prevents progression to CRC. Risk...
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Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
BackgroundHereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but...
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Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes
BackgroundColorectal cancers (CRCs) in the Lynch syndromes have been assumed to emerge through an accelerated adenoma-carcinoma pathway. In this...
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Adenoma characteristics associated with post-polypectomy proximal colon cancer incidence: a retrospective cohort study
BackgroundColorectal cancer (CRC) screening is less effective at reducing cancer incidence in the proximal colon compared to the distal colorectum....
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Progression of duodenal neoplasia to advanced adenoma in patients with familial adenomatous polyposis
BackgroundPatients with familial adenomatous polyposis (FAP) have a lifetime risk of develo** duodenal adenomas approaching 100%, and the relative...
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Inflammatory potential of diet and colorectal carcinogenesis: a prospective longitudinal cohort
BackgroundAcknowledging the role of inflammation in colorectal carcinogenesis, this study aimed to evaluate the associations between diet-associated...
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Azoxymethane/Dextran Sodium Sulfate (AOM/DSS) Model of Colorectal Cancer
Recent progress in develo** new vaccination strategies against cancer requires the production of complex and reliable animal models reflecting the...