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Genoprotective potential of Macaranga species phytochemical compounds on HT-29 human colorectal adenocarcinoma cell line
BackgroundThe species of genus Macaranga are widely found in Malaysian secondary forests and has been used as an alternative for treating varieties...
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Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study
PurposeTo assess whether androgens play a role in explaining the sex related differences in the incidence of colorectal cancer (CRC).
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Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions
BackgroundThe Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior...
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The circadian clock circuitry deconvolutes colorectal cancer and lung adenocarcinoma heterogeneity in a dynamic time-related framework
Increasing evidence imputes cancer progression and resistance to therapy to intra-tumor molecular heterogeneity set off by cancer cell plasticity....
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Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study
BackgroundThis study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC).
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Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness
BackgroundLiver kinase B1 ( LKB1 ) is frequently mutated in lung adenocarcinoma, and its loss contributes to tumor progression.
Methods ...
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Comprehensive analysis of cuproptosis-related long noncoding RNA for predicting prognostic and diagnostic value and immune landscape in colorectal adenocarcinoma
BackgroundCuproptosis, as a copper-induced mitochondrial cell death, has attracted extensive attention recently, especially in cancer. Although some...
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Azoxymethane/Dextran Sodium Sulfate (AOM/DSS) Model of Colorectal Cancer
Recent progress in develo** new vaccination strategies against cancer requires the production of complex and reliable animal models reflecting the...
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Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study
BackgroundThe existence of amino acid metabolic reprogramming in tumor cells is well established. However, the potential correlation between blood...
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Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the...
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Colorectal Cancer and Role of Biomarkers in Diagnosis, Prognostification and Personalized Treatment
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide as per GLOBOCAN 2020. One out of five patients is diagnosed...
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Mucinous Colorectal Cancer Oxidative Stress and Therapeutic MicroRNAs
Colorectal Cancer (CRC) is the third most leading cause of cancer related death worldwide and has a diverse clinical etiology. Mounting evidences has...
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Mucinous Colorectal Cancer Oxidative Stress and Therapeutic MicroRNAs
Colorectal Cancer (CRC) is the third most leading cause of cancer related death worldwide and has a diverse clinical etiology. Mounting evidences has...
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Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Activation of Gasdermin D (GSDMD) results in its cleavage, oligomerization, and subsequent formation of plasma membrane pores, leading to a form of...
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Orthotopic MC-38 Allograft as a Robust Preclinical Model of Colorectal Carcinoma
Colorectal cancer (CRC) is a significant global health concern, requiring effective preclinical models for studying its development and testing...
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A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma
The HAND2-AS1 (HAND2 Antisense RNA 1) Long noncoding RNA (lncRNA) has emerged as a participant in the initiation of various cancer types,...
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Construction of 11 metabolic-related lncRNAs to predict the prognosis in lung adenocarcinoma
ObjectiveTo explore the metabolism-related lncRNAs in the tumorigenesis of lung adenocarcinoma.
MethodsThe transcriptome data and clinical...
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Identification of Cancer-Associated Fibroblasts in Metastatic Lymph Nodes of Colorectal Carcinoma
Cancer-associated fibroblasts (CAF) are a heterogeneous group of tumor microenvironment cells that are barely studied in metastatic lymph nodes. The...
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Analysis of cancer-associated fibroblasts related genes identifies COL11A1 associated with lung adenocarcinoma prognosis
BackgroundThe treatment of lung adenocarcinoma is difficult due to the limited therapeutic options. Cancer-associated fibroblasts play an important...
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Forkhead box E1, frequently downregulted by promoter methylation, inhibits colorectal cancer cell growth and migration
Forkhead box E1 ( FOXE1 ), also known as thyroid transcription factor 2 ( TTF-2 ), belongs to a large family of forkhead transcription factors. It plays...
