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Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse
BackgroundOpting for or against the administration of adjuvant chemotherapy in therapeutic management of stage II colon cancer remains challenging....
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Primary tumour immune response and lymph node yields in colon cancer
BackgroundThe mechanism underlying improved survival in non-metastatic colon cancer with higher lymph node (LN) yield is unknown. This study aimed to...
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How ceramides affect the development of colon cancer: from normal colon to carcinoma
The integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we...
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Role of Tumour-Associated Macrophages in Colon Cancer Progression and Its Therapeutic Targeting
Cancer tissues are invariably infiltrated by cells of the immune system, and macrophages constitute the major portion of these. Experimental pieces...
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Functional proteomics of colon cancer Consensus Molecular Subtypes
BackgroundThe Colorectal Cancer Subty** Consortium established four Consensus Molecular Subtypes (CMS) in colorectal cancer: CMS1...
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The Cancer Stem Cell and Tumour Progression
Tumour stem cells result from genetic or chromosomal changes in normal tissue stem cells, i.e. cells with self-renewal capability. Subsequent tumour...
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Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis
BackgroundThe interleukin (IL)-36 cytokines are a sub-family of the IL-1 family which are becoming increasingly implicated in the pathogenesis of...
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Node-negative colon cancer: histological, molecular, and stromal features predicting disease recurrence
BackgroundWithin the group of node-negative colon cancer patients, presumed to have a good prognosis, a significant percentage of patients develops...
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Location and condition based reconstruction of colon cancer microbiome from human RNA sequencing data
BackgroundThe association between microbes and cancer has been reported repeatedly; however, it is not clear if molecular tumour properties are...
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An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis
As a chronic autoinflammatory condition, ulcerative colitis is often managed via systemic immunosuppressants. Here we show, in three mouse models of...
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Emerging Role of Circulating Tumour DNA in Treatment Response Prognosis in Colon Cancer
Colon cancer is the fourth most commonly diagnosed and second deadliest cancer globally (Bray et al., CA Cancer J Clin. 68:394–424, 2018). Recurrence...
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How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must not only extravasate from...
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The novel FGFR inhibitor F1-7 induces DNA damage and cell death in colon cells
BackgroundFibroblast growth factor receptor (FGFR) signaling influenced tumour occurrence and development. Overexpression of FGFR had been observed...
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Severely polarized extracellular acidity around tumour cells
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer...
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Immunological and prognostic significance of tumour necrosis in colorectal cancer
BackgroundColorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics...
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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines
The clinical prospects of cancer nanomedicines depend on effective patient stratification. Here we report the identification of predictive biomarkers...
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The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery
BackgroundThe impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus,...
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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME)....
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IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration
BackgroundInterleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs...
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Therapeutic targeting of tumour myeloid cells
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloid cells derived from...
