Search
Search Results
-
Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients
BackgroundColibactin, a genotoxin produced by polyketide synthase harboring ( pks + ) bacteria, induces double-strand breaks and chromosome...
-
Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains
BackgroundColibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli ...
-
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
The mucosal epithelium is a common target of damage by chronic bacterial infections and the accompanying toxins, and most cancers originate from this...
-
Screening method toward ClbP-specific inhibitors
BackgroundColibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal...
-
Genoty** of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms
IntroductionColibactin is a small genotoxic molecule produced by enteric bacteria, including certain Escherichia coli ( E. coli ) strains harbored in...
-
Intratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer
BackgroundThis study aimed to investigate clinicopathological and molecular tumour features associated with intratumoral pks + Escherichia coli ( pks + E.coli...
-
Genomic insights into virulence factors affecting tissue-invasive Klebsiella pneumoniae infection
BackgroundThe key virulence factors responsible for hypervirulent Klebsiella pneumoniae (hvKp) infection remains elusive.
MethodsWe analyzed K....
-
Klebsiella pneumoniae Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors
Klebsiella pneumoniae is a Gram-negative pathogen capable of causing a diverse array of infections in humans. It belongs to the group of ESKAPE...
-
Bacteria in cancer initiation, promotion and progression
Cancer cells originate from a series of acquired genetic mutations that can drive their uncontrolled cell proliferation and immune evasion....
-
The emergence of highly resistant and hypervirulent Klebsiella pneumoniae CC14 clone in a tertiary hospital over 8 years
BackgroundKlebsiella pneumoniae is a major bacterial and opportunistic human pathogen, increasingly recognized as a healthcare burden globally. The...
-
-
A geographic cluster of healthcare-associated carbapenemase-producing hypervirulent Klebsiella pneumoniae sequence type 23
Hypervirulent Klebsiella pneumoniae has typically been associated with invasive, community-associated infections. This study describes the molecular,...
-
The microbiota and renal cell carcinoma
Renal cell carcinoma (RCC) accounts for about 2% of cancer diagnoses and deaths worldwide. Recent studies emphasized the critical involvement of...
-
Systemic Onco-Sphere: Host Microbiome and Cancer
In recent years, it has been found that gut microbiota is involved in the metabolism of the host and cancer cells. Interestingly, gut microbiome and...
-
Darmkrebs
Karzinome des Dick- und Enddarms (KolorektalKarzinome, CRC) gehören weltweit zu den am häufigsten auftretenden Krebsarten. Kolorektalkarzinome...
-
Microbe-Induced Oxidative Stress in Cancer Development and Efficacy of Probiotics as Therapeutics in Preventing Its Onset and Progression
Within the metaorganisms, cross-communication between commensal organisms and the host is crucial for the maintenance of physiological homeostasis....
-
Inflammatory bowel disease and carcinogenesis
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer mortality worldwide. Colitis-associated colorectal...
-
Bacteraemia associated with multiple septic localizations caused by Klebsiella pneumoniae sequence type ST660
We report a case of Klebsiella pneumoniae bacteraemia in an 80-year-old man in France with no history of travel to Asia, complicated by endogenous...
-
Colorectal Cancer
Carcinomas of the colon and rectum (colorectal cancer, CRC) are among the most prevalent cancers worldwide. Colorectal cancers develop through a...
-
Brief report: community-acquired Friedlander’s pneumonia and pulmonary metastatic Klebsiella pneumoniae infection caused by hypervirulent ST23 in the Netherlands
Infections with hypervirulent Klebsiella pneumoniae (hvKp) commonly presents with primary liver infection, bacteremia, and metastatic abscesses....
