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The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats
RationaleCocaine use disorder (CUD) is a brain disorder for which there is no Food and Drug Administration-approved pharmacological treatment....
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Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats
Cocaine addiction is a complex pathology inducing long-term neuroplastic changes that, in turn, contribute to maladaptive behaviors. This behavioral...
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Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking
RationaleCocaine can increase inflammatory neuroimmune markers, including chemokines and cytokines characteristic of innate inflammatory responding....
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Renewal of cocaine seeking using social and nonsocial contextual stimuli
RationaleVarious nonsocial cues have been used as stimuli to examine the contextual control of drug seeking behavior, but little is known about the...
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Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk
BackgroundIndividuals with schizophrenia have high rates of comorbid substance use problems. One potential explanation for this comorbidity is...
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Extended Drug Access and Escalation of Drug Self-Administration
In this chapter we first describe the intravenous drug self-administration technique in rats, with a focus on cocaine. Where relevant, we also...
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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues
RationaleWhen people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include...
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Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving
RationaleIncubation of cocaine craving refers to the progressive intensification of cue-induced craving during abstinence from cocaine...
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D-amphetamine maintenance therapy reduces cocaine use in female rats
RationaleD-amphetamine maintenance therapy is a promising strategy to reduce drug use in cocaine use disorder (addiction). In both male rats and...
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The secondary visual cortex mediated the enhancement of associative learning on methamphetamine self-administration behaviors
RationaleMethamphetamine addiction is a persistent and intractable pathological learning and memory, whereas no approved therapeutics is available....
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Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats
RationaleAfter a history of intermittent cocaine intake, rats develop patterns of drug use characteristic of substance use disorder. The dorsal...
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Effects of environmental and pharmacological manipulations on cocaine-vs-negative reinforcer choice in male and female rats
RationaleThe adverse consequences of human addictive drug use could be the result of either addictive drug consumption resulting in punishment (e.g.,...
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Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration
Methamphetamine (MA) is one of the most abused drugs globally, but the mechanism of its addiction remains unclear. Several animal studies have shown...
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Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys
RationalePrevious studies in socially housed monkeys examining acquisition of cocaine self-administration under fixed-ratio (FR) schedules of...
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The effects of gonadal hormones on heroin Self-Administration in male gonadectomized rats
RationalePrevious studies have shown that gonadal hormones influence opioid self-administration in female rodents, but very few studies have examined...
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Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration
RationaleIn classical conditioning, sign-tracking reflects behavior directed toward a conditioned stimulus (CS) in expectation of a reward...
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Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration
RationaleThe probability of structural remodeling in brain circuits may be modulated by molecules of perineuronal nets (PNNs) that restrict neuronal...
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Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats
RationaleAn important facet of cocaine addiction is a high propensity to relapse, with increasing research investigating factors that predispose...
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Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales
Rationale and ObjectivesThe prefrontal cortex is critical for execution and inhibition of reward seeking. Neural manipulation of rodent medial...
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The imidazoline I2 receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination
RationaleIncreasing evidence shows that imidazoline I 2 receptor agonists enhance opioid-induced analgesia, suggesting that the combination of I 2 ...
