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Genetic diversity and molecular evolution of sugarcane mosaic virus, comparing whole genome and coat protein sequence phylogenies
Sugarcane mosaic virus (SCMV) is a widely distributed potyvirus that causes mosaic disease in sugarcane, maize, sorghum, canna, and other monocot...
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A single amino acid at position 31 in the N-terminus of the coat protein of cucumber mosaic virus determines its avirulence function for RCY1-conferred virus resistance
The coat protein (CP) of the cucumber mosaic virus (CMV) yellow strain [CMV(Y)], but not the CMV B2 strain [CMV(B2)], serves as an avirulence...
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Buffy coat signatures of breast cancer risk in a prospective cohort study
BackgroundEpigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily...
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PKHD1L1, a gene involved in the stereocilia coat, causes autosomal recessive nonsyndromic hearing loss
Identification of genes associated with nonsyndromic hearing loss is a crucial endeavor given the substantial number of individuals who remain...
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Down Regulation of Potato Virus Y (PVY) Coat Protein (CP) Expression by Iberis gibraltarica Protein Extract
AbstractPotato virus Y (PVY) is among the most destructive potato viruses and a solemn threat to efficient seed production worldwide. Almost 70%...
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Doxycycline-Loaded Calcium Phosphate Nanoparticles with a Pectin Coat Can Ameliorate Lipopolysaccharide-Induced Neuroinflammation Via Enhancing AMPK
Neuroinflammation occurs in response to different injurious triggers to limit their hazardous effects. However, failure to stop this process can end...
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Protein–Protein Interaction via Two-Hybrid Assay in Yeast
The yeast two-hybrid assay enables detecting interactions between proteins, which makes this tool of particular interest for plant–virus interaction...
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Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption
Understanding the interactions between nanocarriers and plasma proteins is essential for controlling their biological fate. Based on the reported...
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Geographically distant isolates of the persistent southern tomato virus (STV) show very low genetic diversity in the putative coat protein gene
Southern tomato virus (STV) from genus Amalgavirus (Family Amalgaviridae ) is a persistent virus infecting tomato crops worldwide. Information on...
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Molecular characterization and identification of Stellaria aquatica virus C, a novel putative member of the genus Closterovirus infecting Stellaria aquatica in South Korea
A novel virus infecting Stellaria aquatica plants, tentatively named "Stellaria aquatica virus C" (StAVC), was identified in Gangwon-do Province,...
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Empowering gene delivery with protein engineering platforms
The repertoire of therapeutic proteins has been substantially augmented by molecular engineering approaches, which have seen remarkable advancement...
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Stability and Characterization of Protein- and Nucleotide-Based Therapeutics
Throughout the development process of protein or nucleotide-based therapeutics, a broad array of analytical techniques is applied on a routine basis...
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Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is regulated by over 40 enzymes, targeting more than...
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Homological Series in the Variability of the Coat Color in Fur Animals
AbstractPhenotypic parallelism has been established with similar aberrations of coat color in sables and northern fur seals with known fur color...
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Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19
During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such...
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Glycosaminoglycan Analysis: Purification, Structural Profiling, and GAG–Protein Interactions
Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all...
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Creating Artificial Viruses Using Self-assembled Proteins and Polypeptides
Viruses are extraordinary entities that have inspired biomolecular engineers to craft artificial versions of them. Recently, multiple efforts have...
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Characterization of the functional domains of nuclear shuttle protein (NSP) of Indian cassava mosaic virus using green fluorescent protein as reporter
Indian cassava mosaic virus (ICMV), responsible for the cassava mosaic disease in India, harbours two circular genomic components, DNA-A and DNA-B;...
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Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis
BackgroundProtein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic...
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The 2b protein and C-terminal region of the 2a protein indispensably facilitate systemic movement of cucumber mosaic virus in radish with supplementary function by either the 3a or the coat protein
BackgroundIn Raphanus sativus (Japanese radish), strain D8 of cucumber mosaic virus (CMV-D8) establishes a systemic infection and induces mild...
