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The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19
BackgroundFrailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes...
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First Co-morbidity of Lophomonas blattarum and COVID-19 Infections: Confirmed Using Molecular Approach
IntroductionLophomoniasis is caused by Lophomonas spp., a new emerging protozoan, which commonly affects the human lower respiratory tract. The Lophomonas...
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Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India
BackgroundUnderstanding the immune correlates of cardiovascular disease (CVD) risk in HIV infection is an important area of investigation in the...
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Morbidity of Scabies in Resource-Poor Communities
Morbidity and clinical features in resource-poor communities are considerably different from high-income settings. Severe itching, pain, sleep...
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Determine the factors affecting the time to recovery of children with bacterial meningitis at Jigjiga university referral hospital in the Somali Regional State of Ethiopia: using the parametric shared frailty and AFT models
BackgroundNeisseria meningitides, Streptococcus pneumonia, and hemophilic influenza type B are frequently linked to bacterial meningitis (BM) in...
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Steroidal lactones from Withania somnifera effectively target Beta, Gamma, Delta and Omicron variants of SARS-CoV-2 and reveal a decreased susceptibility to viral infection and perpetuation: a polypharmacology approach
Prevention from disease is presently the cornerstone of the fight against COVID-19. With the rapid emergence of novel SARS-CoV-2 variants, there is...
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The impact of COVID on bacterial sepsis
PurposeTo identify the predictors of morbidity and mortality in matched COVID-19 positive and negative patients who were septic with Gram positive or...
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Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model
BackgroundEpidemiological studies have related desert dust events to increased respiratory morbidity and mortality. Although the Sahara is the...
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Scabies-Associated Microbiota
Globally, scabies causes substantial morbidity and mortality. In the tropics, scabies promotes opportunistic bacterial infections, leading to...
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A Registry Study of 240 Patients with X-Linked Agammaglobulinemia Living in the USA
PurposeTo understand the natural history and clinical outcomes for patients with X-linked agammaglobulinemia (XLA) in the United States utilizing the...
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Risk factors, outcomes, and epidemiological and etiological study of hospitalized COVID-19 patients with bacterial co-infection and secondary infections
BackgroundAs a common complication of viral respiratory tract infection, bacterial infection was associated with higher mortality and morbidity....
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A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
BackgroundChanges in cell-type composition of tissues are associated with a wide range of diseases and environmental risk factors and may be causally...
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Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning
IntroductionCarbon monoxide (CO) is a colorless and odorless gas that is a leading cause of environmental poisoning in the USA with substantial...
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Aberrant activation of AXL may drive progression of squamous cell carcinoma in CLL patients: a mechanistic study with clinical implications
BackgroundOccurrence of squamous cell carcinoma (SCC) even in early-stage, untreated chronic lymphocytic leukemia (CLL) patients can be a significant...
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When to Initiate Antifungal Treatment in COVID-19 Patients with Secondary Fungal Co-infection
Purpose of ReviewSevere-acute respiratory coronavirus 2 (SARS-CoV-2) has been driving the health care delivery system for over 2 years. With time,...
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Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning
IntroductionCarbon monoxide (CO) is a colorless and odorless gas that is a leading cause of environmental poisoning in the USA with substantial...
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Integrated analysis and exploration of potential shared gene signatures between carotid atherosclerosis and periodontitis
BackgroundIncreasing evidence has suggested an association between carotid atherosclerosis (CAS) and periodontitis (PD); however, the mechanisms have...
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Resolving neutrophils due to TRAM deletion renders protection against experimental sepsis
ObjectiveProper inflammation resolution is crucial to prevent runaway inflammation during sepsis and reduce sepsis-related mortality/morbidity....
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Potentially inappropriate medication use and mortality in patients with cognitive impairment
PurposePotentially inappropriate medications (PIMs) are associated with falls, hospitalization, and cognitive decline. Few studies have investigated...
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Modulation of innate immunity related genes resulting in prophylactic antimicrobial and antiviral properties
BackgroundThe innate immunity acts during the early phases of infection and its failure in response to a multilayer network of co-infections is cause...
