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A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients
BackgroundThis study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized...
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Revisiting the Biological and Clinical Impact of CDH1 Missense Variants
E-cadherin, encoded by CDH1, plays an undisputable role in mechanical and biochemical signals that are crucial for cell integrity and tissue...
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Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
DNA methylation analysis has become a powerful tool in neuropathology. Although DNA methylation-based classification usually shows high accuracy,...
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Clinical impact of preemptive pharmacogenomic testing on antiplatelet therapy in a real-world setting
CYP2C19 genoty** to guide antiplatelet therapy after patients develop acute coronary syndromes (ACS) or require percutaneous coronary interventions...
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Cellular and clinical impact of protein phosphatase enzyme epigenetic silencing in multiple cancer tissues
BackgroundProtein Phosphatase Enzymes (PPE) and protein kinases simultaneously control phosphorylation mechanisms that tightly regulate intracellular...
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The acceptability and clinical impact of using polygenic scores for risk-estimation of common cancers in primary care: a systematic review
BackgroundPolygenic scores (PGS) have been developed for cancer risk-estimation and show potential as tools to prompt earlier referral for high-risk...
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Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
IntroductionThe first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial...
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Medical School Clinical Trials Educational Intervention: Impact on Knowledge and Attitudes
Medical student knowledge and opinions of clinical research have important ramifications for how likely they will be to refer patients into clinical...
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Estimating the impact of improved management of haemophilia a on clinical outcomes and healthcare utilisation and costs
ObjectiveHaemophilia A (HA) is associated with high clinical and healthcare burden. We developed an Excel-based model comparing current practice to...
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Clinical Pharmacokinetic Studies
Drug efficacy and response are a function of drug concentration over time. In clinical pharmacokinetic studies, aspects of drug absorption,...
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The assessment of the clinical impact of using a single set of radiotherapy planning data for two kilovoltage therapy units
Kilovoltage therapy units are used for superficial radiotherapy treatment delivery. Peer reviewed studies for MV linear accelerators describe...
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Impact of Clinical Trial Design on Recruitment of Racial and Ethnic Minorities
Knowledge related to how oncology treatment trial design influences enrollment of racial and ethnic minorities is limited. Rigorous identification of...
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Biosimilars in Clinical Trials
Clinical trials impose validation of safety and efficacy, and biosimilars have contributed large share to the pipeline of clinical trials. These...
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The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial
Adverse drug events (ADEs) account for a significant mortality, morbidity, and cost burden. Pharmacogenetic testing has the potential to reduce ADEs...
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Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers
The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)- and/or carbapenemase-producing Enterobacterales ( Ent ) has reached...
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Clinical impact of metformin exposure during Staphylococcus aureus bacteremia in patients with diabetes mellitus
PurposeIncreasing evidence has suggested that metformin may play positive roles in a wide range of infectious diseases. This study aimed to...
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The impact of the COVID-19 pandemic in the clinical assistance to breast cancer patients
PurposeWe aimed to disclose the impact of the pandemic on breast cancer patients in a specialized breast cancer center (BCC).
Methods ...
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Impact of COVID-19 Pandemic on Clinical Care of Patients and Psychosocial Health of Affected Families with Chronic Granulomatous Disease: an Observational Study from North India
Day-to-day clinical management of patients with inborn errors of immunity, including chronic granulomatous disease (CGD), has been affected by the...
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Sha** Clinical Reasoning
Clinical reasoningReasoning, clinical is at the core of all healthHealth-related professions, and it is long recognized as a critical skillSkill for...
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The INFINITY study protocol: a retrospective cohort study on decision making and clinical impact of biomarker-driven precision oncology in routine clinical practice
BackgroundPrecision oncology, defined as treatment of patients with targeted therapies matched to specific molecular alterations, has entered routine...