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Clinical research stakeholders’ experiences of clinical research during COVID-19: a qualitative study
BackgroundThe COVID-19 pandemic created a complex high-risk clinical research environment with clinical research activities significantly impacted....
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Advanced Therapy Medicinal Products: Clinical, Non-clinical, and Quality Considerations
Cell therapy, tissue engineering, and gene therapy products, together called “advanced therapy medicinal products” (ATMPs), represent a heterogeneous...
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Gene–environment interactions in human health
Gene–environment interactions (G × E), the interplay of genetic variation with environmental factors, have a pivotal impact on human complex traits...
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Phases of Clinical Trials
Clinical trials are trials conducted on human subjects. Clinical trials of an investigational drug product (IDP) that are intended to support drug...
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Randomized Clinical Trials
Observational studies suffer from biases and confounding, which can never be completely eliminated. Whenever feasible and ethically appropriate, a...
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The Disadvantages of Automation in Clinical Microbiology
The procedures of clinical microbial diagnosis are complicated and expensive, the potential advantages expected from implementation of Total...
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Dynamics of Staphylococcus aureus in patients and the hospital environment in a tertiary care hospital in the Netherlands
BackgroundThe dynamics of Staphylococcus aureus in patients and the hospital environment are relatively unknown. We studied these dynamics in a...
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Genotype × environment interactions in gene regulation and complex traits
Genotype × environment interactions (GxE) have long been recognized as a key mechanism underlying human phenotypic variation. Technological...
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The Environment and Headache: a Narrative Review
Purpose of ReviewIn this narrative review, we summarize the peer-reviewed literature published between 2017 and 2022 that evaluated ambient...
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Fractal Analysis in Clinical Neurosciences: An Overview
Over the last years, fractals have entered into the realms of clinical neurosciences. The whole brain and its components (i.e., neurons and...
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Phenomenological Evaluation of an Undergraduate Clinical Needs Finding Skills Through a Virtual Reality Clinical Immersion Platform
Clinical immersion programs have been widely used in higher education, particularly in biomedical engineering (BME) programs, to allow students to...
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Clinical Pharmacological Considerations in Transgender Medicine
Transgender medicine is a growing clinical field. Hormone therapy (testosterone or estrogen treatment) is part of the standard of gender-affirming...
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Clinical Applications of 3D Printed Drug Products
Common challenges in pharmaceutical formulation development and clinical manufacturing include manual labor and a lack of flexibility to formulate a...
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Map** the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment
BackgroundThe rise of linezolid resistance has been widely observed both in clinical and non-clinical settings. However, there were still data gaps...
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Clinical Scoring of Disease Activity in Animal Models
Disease severity in murine arthritis models, such as collagen-induced arthritis (CIACollagen-induced arthritis (CIA)), is commonly assessed by...
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Neurotrophic Factors in Parkinson’s Disease: Clinical Trials
Introduction: Parkinson’s disease (PD)Parkinson’s disease is characterized by the progressive loss of midbrain dopamine (DA) neurons that regulate...
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Gene–environment interactions and their impact on human health
The molecular processes underlying human health and disease are highly complex. Often, genetic and environmental factors contribute to a given...
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Clinical Bioinformatics
Clinical bioinformatics is a powerful discipline that covers the development of various computational models describing initiation and progression of...
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Pet cats may shape the antibiotic resistome of their owner’s gut and living environment
BackgroundCompanion animals can contribute to the physical and mental health of people and often live in very close association with their owners....
