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Alleviation of cholestatic liver injury and intestinal permeability by lubiprostone treatment in bile duct ligated rats: role of intestinal FXR and tight junction proteins claudin-1, claudin-2, and occludin
Gut barrier disintegrity and endotoxin translocation to the liver and systemic circulation are serious clinical complications associated with the...
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Teriflunomide Promotes Blood–Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis
The blood–brain barrier (BBB) and tight junction (TJ) proteins maintain the homeostasis of the central nervous system (CNS). The dysfunction of BBB...
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Alteplase Improves Neurological Function and Affects Expression of SDF-1 and Claudin-5 in Rats with Acute Cerebral Infarction
AbstractWe aimed to explore the effects of alteplase on neurological function and expression of stromal cell-derived factor-1 (SDF-1) and Claudin-5...
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Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier
AbstractClaudin-5 is one of the most essential tight junction proteins at the blood-brain barrier. A single nucleotide polymorphism rs10314 is...
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Targeting Caveolin-1 and Claudin-5 with AY9944, Improve Blood–Brain Barrier Permeability; Computational Simulation and Experimental Study
AbstractThe current study aimed to determine the protective effect of AY9944 related to Caveolin-1 and Claudin-5 role in lipid raft, which can rescue...
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Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation
BackgroundTriple-negative breast cancers (TNBC) have a relatively poor prognosis and responses to targeted therapies. Between 25 and 39% of TNBCs are...
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Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy
AbstractDiabetic polyneuropathy (DPN) is the most common complication in diabetes and can be painful in up to 26% of all diabetic patients....
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The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats
Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular...
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Regulation of tight junction proteins and cell death by peroxisome proliferator-activated receptor γ agonist in brainstem of hypertensive rats
The decrease in tight junction proteins and their adapter proteins in the hypertensive brain is remarkable. Here, we aimed to investigate tight...
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Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway
Immunohistochemical microarray comprising 80 patients with esophageal squamous cell carcinoma (ESCC) and discovered that the expression of CLDN1 and CLDN4...
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ZNF787 and HDAC1 Mediate Blood–Brain Barrier Permeability in an In Vitro Model of Alzheimer’s Disease Microenvironment
The permeability of the blood–brain barrier (BBB) is increased in Alzheimer’s disease (AD). This plays a key role in the instigation and maintenance...
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Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100β under high-altitude conditions
Damage to the intestinal epithelial barrier (IEB) has been reported under high-altitude (HA) conditions and may be responsible for HA-associated...
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Inhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood–Brain Barrier Disruption and Neuronal Damage
The disruption of the blood–brain barrier (BBB) is hypothesized to be involved in the progression of anti- N -methyl- d -aspartate receptor (NMDAR)...
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All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4
Invasive apocrine carcinoma of the breast is an uncommon triple negative tumour that lacks a specific therapeutic target. Apocrine metaplasia of the...
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Claudin-Targeted Suicide Gene Therapy for Claudin-Overexpressing Tumor Cells by Using Modified Clostridium perfringens Enterotoxin (CPE)
Bacterial toxins gain growing attention as potential cancer treatment due to their potent cytotoxic effects. Among the very different toxins with...
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Study on the mechanism of hirudin multi target delaying renal function decline in chronic kidney disease based on the “gut-kidney axis” theory
The disorder of the “gut-kidney axis” exacerbates renal function decline in chronic kidney disease (CKD), and current CKD therapy is insufficient to...
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Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis
Neurotropic viruses can infiltrate the CNS by crossing the blood–brain barrier (BBB) through various mechanisms including paracellular,...
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Gastrointestinal consequences of lipopolysaccharide-induced lung inflammation
BackgroundRespiratory inflammation is the body’s response to lung infection, trauma or hypersensitivity and is often accompanied by comorbidities,...
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The miR-199a-5p/PD-L1 axis regulates cell proliferation, migration and invasion in follicular thyroid carcinoma
BackgroundFollicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid and easily develops into distant metastasis. PD-L1 is...
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Histone Deacetylase 3 Inhibition Decreases Cerebral Edema and Protects the Blood–Brain Barrier After Stroke
We have previously shown that selective inhibition of histone deacetylase 3 (HDAC3) decreases infarct volume and improves long-term functional...
