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Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice
BackgroundAlzheimer's disease is accompanied by an abnormal high accumulation of cis-P tau. However, the long-term changes in behavior following tau...
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Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
BackgroundAntibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in...
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Glucose Starvation Causes ptauS409 Increase in N2a Cells Through ATF3/PKAcα Signaling Pathway
In this work, we report that glucose starvation (GS) causes p tau S409 increase, which may participate in GS-induced neurites retraction in neuro-2a...
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Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela
Spinal cord injury (SCI) can result in significant neurological impairment and functional and cognitive deficits. It is well established that SCI...
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Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been...
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Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias
BackgroundThe levels of synaptic markers synaptosomal-associated protein 25 (SNAP-25) and neurogranin (Ng) have been shown to increase early in the...
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Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests
With the emergence of Alzheimer’s disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes...
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Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis
BackgroundMeasurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive...
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Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease
BackgroundIn Alzheimer’s disease (AD), fibrillar tau initially occurs locally and progresses preferentially between closely connected regions....
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Mendelian Randomization Identifies Genetically Supported Drug Targets for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Currently, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have no effective treatments. Drug repurposing offers a rapid method...
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Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer’s disease neuropathological...
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Tau Pathology Triggered by Spinal Cord Injury Can Play a Critical Role in the Neurotrauma Development
Traumatic spinal cord injury (SCI) can result in substantial neurological impairment along with significant emotional and psychological distress. It...
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Performance of plasma phosphorylated tau 181 and 217 in the community
Plasma phosphorylated tau 181 (P-tau181) and 217 (P-tau217) are indicators of both amyloid and tau pathology in clinical settings, but their...
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Serum immunoglobulins and biomarkers of dementia: a population-based study
BackgroundInflammation plays a key role in the development of dementia, but its link to early biomarkers, particularly those in plasma or...
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Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy
BackgroundCortical atrophy is associated with cognitive decline, but the association is not perfect. We aimed to identify factors explaining the...
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Effects of certain pre-analytical factors on the performance of plasma phospho-tau217
IntroductionPre-analytical factors can cause substantial variability in the measurements of cerebrospinal fluid (CSF) and plasma biomarkers of...
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Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals
BackgroundIndividuals on the preclinical Alzheimer's continuum, particularly those with both amyloid and tau positivity (A + T +), display a rapid...
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Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain
The relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated...
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Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers
BackgroundLoss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer’s disease (AD). The role of pericyte in...
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Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
BackgroundGiven that tau accumulation, not amyloid-β (Aβ) burden, is more closely connected with cognitive impairment in Alzheimer’s disease (AD), a...
