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Viral Tools for Neural Circuit Tracing
Neural circuits provide an anatomical basis for functional networks. Therefore, dissecting the structure of neural circuits is essential to...
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Neurotropic Viruses as a Tool for Neural Circuit-Tracing
AbstractThe brain is the most important organ of mammals. The infinitely complex network of special synaptic connections constitutes the main body of...
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Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide
Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function. Recent advances in optogenetics, neuronal ty** and...
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Lighting Up Neural Circuits by Viral Tracing
Neurons are highly interwoven to form intricate neural circuits that underlie the diverse functions of the brain. Dissecting the anatomical...
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Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) imposes a significant burden on patients, and the volume of hematoma plays a crucial role in determining the severity...
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A Novel Mouse Model for Polysynaptic Retrograde Tracing and Rabies Pathological Research
Retrograde tracing is an important method for dissecting neuronal connections and map** neural circuits. Over the past decades, several virus-based...
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Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing to poor understanding of its cells and circuits. It was...
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Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus
The thalamocortical (TC) circuit is closely associated with pain processing. The hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 channel...
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Generation and Application of Engineered Rabies Viral Vectors for Neural Circuit Research
To understand how the brain functions, it is essential to reveal how neural circuits in the brain give rise to perception, cognition, and behavior....
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The cognitive impact of light: illuminating ipRGC circuit mechanisms
Ever-present in our environments, light entrains circadian rhythms over long timescales, influencing daily activity patterns, health and performance....
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A brainstem circuit for phonation and volume control in mice
Mammalian vocalizations are critical for communication and are produced through the process of phonation, in which expiratory muscles force air...
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Map** Synaptic Inputs to Oligodendroglial Cells Using In Vivo Monosynaptic Viral Tracing
Oligodendroglial precursor cells (OPCs) are a non-neuronal cell type in the brain that receives synaptic inputs. Electrophysiological and...
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Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
BackgroundAbnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD)....
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Recombinase-independent AAV for anterograde transsynaptic tracing
Viral transsynaptic labeling has become indispensable for investigating the functional connectivity of neural circuits in the mammalian brain....
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Investigations of brain-wide functional and structural networks of dopaminergic and CamKIIα-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies
BackgroundThe ventral tegmental area (VTA) contains heterogeneous cell populations. The dopaminergic neurons in VTA play a central role in reward and...
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A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling
BackgroundViral tracers are important tools for map** brain connectomes. The feature of predominant anterograde transneuronal transmission offers...
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Neural dynamics and architecture of the heading direction circuit in zebrafish
Animals generate neural representations of their heading direction. Notably, in insects, heading direction is topographically represented by the...
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Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety
Anxiety disorders are currently a major psychiatric and social problem, the mechanisms of which have been only partially elucidated. The hippocampus...
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A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior
Licking behavior is important for water intake. The deep mesencephalic nucleus (DpMe) has been implicated in instinctive behaviors. However, whether...
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Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons
The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined centers that engage in the autonomic regulation of...
