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Chronopharmacology in Drug Development
The human body is highly organized in time and most functions display significant daily [circadian] and seasonal rhythms. Gene expression in the...
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Control of Arterial Hypertension by the AhR Blocker CH-223191: A Chronopharmacological Study in Chronic Intermittent Hypoxia Conditions
Chronic intermittent hypoxia (CIH) is a major contributor to the development of hypertension (HTN) in obstructive sleep apnea (OSA). OSA subjects...
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Chronopharmacology
Rhythmic variations in various physiological, biochemical, and behavioral parameters occur in all living organisms including humans. These variations...
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Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions
Circadian rhythms are ubiquitous phenomena that recur daily in a self-sustaining, entrainable, and oscillatory manner, and orchestrate a wide range...
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Circadian Rhythms: Physiological and Pathophysiological Aspects
Physiological and pathophysiological aspects of the functioning of the cerebral system (hypothalamus and cerebral epiphysis) providing the circadian...
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Repurposing of IL 33/ST2 Modulating Drugs as a Cardioprotective Agent: A Promising Approach
Drug repurposing has emerged as an enigmatic clinical approach in disorders affecting the cardiovascular system. The concept of drug repurposing has...
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Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
BackgroundTolerability and antitumour efficacy of chemotherapy and radiation therapy can vary largely according to their time of administration along...
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Exploring the link between chronobiology and drug delivery: effects on cancer therapy
Circadian clock is an impressive timing system responsible for the control of several metabolic, physiological and behavioural processes. Nowadays,...
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A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients
Sleep is a basic need that is frequently set aside in modern societies. This leads to profound but complex physiological maladaptations in the body...
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Neutrophils in chronic inflammatory diseases
Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide. Chronic inflammation is...
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Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach
Since the outbreak of the first SARS-CoV-2 epidemic in China, pharmacists have rapidly engaged and developed strategies for pharmaceutical care and...
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Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases
Successful clinical development of new therapeutic interventions is notoriously difficult, especially in neurodegenerative diseases, where predictive...
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Identification of potential therapeutic targets for atherosclerosis by analysing the gene signature related to different immune cells and immune regulators in atheromatous plaques
BackgroundAtherosclerosis is a chronic inflammatory disease that affects multiple arteries. Numerous studies have shown the inherent immune diversity...
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Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling Technology
Hydrocortisone (HC) is the optimal drug for adolescents diagnosed with congenital adrenal hyperplasia (CAH). Because traditional dosage regimens HC...
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Preparation and Evaluation of Dual–release Esomeprazole Magnesium Pulsed Capsules Filled with Two Kinds of Enteric-coated Pellets
PurposeThis study aims to develop dual–release esomeprazole magnesium (EMZ-Mg) pulsed capsules for more effective inhibition of gastric acid...
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Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design
To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed...
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Decoding the tumor microenvironment with spatial technologies
Visualization of the cellular heterogeneity and spatial architecture of the tumor microenvironment (TME) is becoming increasingly important to...
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The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic
Twenty-four-hour rhythms in immune parameters and functions are robustly observed phenomena in biomedicine. Here, we summarize the important role of...
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Chronopharmacology in Drug Development
The human body is highly organized in time and most functions display significant daily [circadian] and seasonal rhythms. Gene expression in the...