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Enhanced intrathalamic morphological connectivity in patients with chronic insomnia
This study aimed to systematically investigate abnormal morphological connectivity in subregions of the thalamus and examine the clinical relevance...
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TBSS analysis of white matter fasciculus in chronic insomnia and the relationship with sleep quality and cognitive function
Eighty patients with chronic insomnia and 50 normal controls were selected. Evaluation scales included Pittsburgh Sleep Quality Index, Dysfunctional...
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Static and temporal dynamic alterations of regional homogeneity in chronic insomnia: a resting-state fMRI study
To explore brain function alterations in chronic insomnia (CI). 65 CI patients and 48 healthy controls were included to analyze abnormal alterations...
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Natural Immunosuppressants as a Treatment for Chronic Insomnia Targeting the Inflammatory Response Induced by NLRP3/caspase-1/IL-1β Axis Activation: A Scoo** Review
Chronic insomnia is an inflammatory-related disease with an important pathological basis for various diseases which is a serious threat to a person’s...
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Management of Chronic Insomnia Using Cognitive Behavior Therapy for Insomnia (CBT-I) During COVID-19 Pandemic: Does One Shoe Fit All?
PurposeInsomnia is a highly prevalent disorder that is seen across all age groups causing significant morbidity to the patients. Its prevalence has...
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Insomnia-related rodent models in drug discovery
Despite the widespread prevalence and important medical impact of insomnia, effective agents with few side effects are lacking in clinics. This is...
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Behavioral Presentations of Insomnia
Insomnia is a common disorder that results in short sleep at night along with daytime symptoms, for example, fatigue, lethargy, poor concentration,...
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Management of chronic insomnia using hypnotics: a friend or a foe?
Epidemiological studies suggest that 10–15% adults meet the present criteria for the diagnosis of insomnia disorder; however, there may be...
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Towards a personalized prediction, prevention and therapy of insomnia: gut microbiota profile can discriminate between paradoxical and objective insomnia in post-menopausal women
BackgroundInsomnia persists as a prevalent sleep disorder among middle-aged and older adults, significantly impacting quality of life and increasing...
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Sleep Immune Cross Talk and Insomnia
Sleep and immunity have bidirectional relationships. In this chapter, we review the links between sleep and immunity, focusing on immune changes...
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Diagnosis and Management of OSA Comorbid with Insomnia (COMISA)
Research addressing comorbid insomnia with obstructive sleep apnea (OSA) (COMISA) has been conducted in two different ways—firstly, looking for the...
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Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial
BackgroundCOMISA is a common disorder that results in nighttime awakenings ,daytime sleepiness and PAP intolerance. Cognitive behavioral therapy for...
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Comparison of the effects of cognitive-behavioral therapy for insomnia between patients with primary insomnia and comorbid insomnia
Cognitive behavioral therapy for insomnia (CBT-I) is effective for not only primary insomnia (PI) but also comorbid insomnia (CI; insomnia associated...
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Anti-insomnia Effect of a Polyherbal Formulation on P-chlorophenyalanine Induced Experimental Animal Model
Sleep is a dynamic and controlled set of physiological and behavioural practices during which the stabilisation and restoration processes of the body...
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Altered morphometric similarity networks in insomnia disorder
Previous studies on structural covariance network (SCN) suggested that patients with insomnia disorder (ID) show abnormal structural connectivity,...
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Reduced left lateralized functional connectivity of the thalamic subregions between short-term and chronic insomnia disorder
The purpose of the study was to systematically investigate the structural and functional abnormalities in the subregions of the thalamus and to...
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Insomnia complaints correlated with higher risk of cognitive impairment in older adults following stroke: a National Representative Comparison Study
Although associations among insomnia, cognitive impairment, and stroke have been demonstrated, whether insomnia increases the risk of cognitive...
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Altered neurophysiological responses during empathy for pain in insomnia: evidence from an EEG study in non-clinical samples
BackgroundThis study aims to investigate the behavioral and neurophysiological changes accompanying the empathy for pain among individuals with...
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Genetic study of the causal effect of lipid profiles on insomnia risk: a Mendelian randomization trial
ObjectivesIn response to the controversy surrounding observational studies of the association between lipid profiles and the risk of insomnia, the...
