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Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and studying molecular players implicated in the epigenetic regulation...
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DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration
Neurodegenerative diseases have a complex origin and are composed of genetic and environmental factors. Both DNA damage and chromatin rearrangement...
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Chromatin modifiers in human disease: from functional roles to regulatory mechanisms
The field of transcriptional regulation has revealed the vital role of chromatin modifiers in human diseases from the beginning of functional...
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The chromatin-associated RNAs in gene regulation and cancer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into proteins or execute gene regulatory functions. Many RNAs...
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Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human genetic studies demonstrate...
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In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
Cellular differentiation requires extensive alterations in chromatin structure and function, which is elicited by the coordinated action of chromatin...
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Five years of experience in the Epigenetics and Chromatin Clinic: what have we learned and where do we go from here?
The multidisciplinary Epigenetics and Chromatin Clinic at Johns Hopkins provides comprehensive medical care for individuals with rare disorders that...
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Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a multifactorial disease highly influenced by environmental...
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Oncogenic signaling-mediated regulation of chromatin during tumorigenesis
Signaling pathways play critical roles in executing and controlling important biological processes within cells. Cells/organisms trigger appropriate...
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CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway
BackgroundThe dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but...
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Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
BackgroundIndividuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism...
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Profiling the Epigenetic Landscape of the Tumor Microenvironment Using Chromatin Immunoprecipitation Sequencing
Cancer cells within a tumor exhibit phenotypic plasticity that allows adaptation and survival in hostile tumor microenvironments. Reprogramming of...
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RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing...
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Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program
BackgroundEpigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the...
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The language of chromatin modification in human cancers
The genetic information of human cells is stored in the context of chromatin, which is subjected to DNA methylation and various histone...
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Interplay between chromatin marks in development and disease
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have important roles in transcriptional regulation. Although many reports...
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Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer
BackgroundTargeting vulnerabilities of cancer cells by inhibiting key regulators of cell proliferation or survival represents a promising way to...
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The emerging role of ISWI chromatin remodeling complexes in cancer
Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily...
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Effects of inhibiting astrocytes and BET/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer’s disease
Communication between astrocytes and neurons has a profound effect on the pathophysiology of Alzheimer’s disease (AD). Astrocytes regulate...
