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A tumor microenvironment-based prognostic index for osteosarcoma
BackgroundThe tumor microenvironment (TME) has a central role in the oncogenesis of osteosarcomas. The composition of the TME is essential for the...
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Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
BackgroundLuteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, the mechanisms of...
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Exploring the relationship between metabolism and immune microenvironment in osteosarcoma based on metabolic pathways
BackgroundMetabolic remodeling and changes in tumor immune microenvironment (TIME) in osteosarcoma are important factors affecting prognosis and...
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Abnormal signal pathways and tumor heterogeneity in osteosarcoma
BackgroundOsteosarcoma (OS) is the most frequent and aggressive primary malignant sarcoma among adolescents and chemotherapy has not substantially...
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Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling
BackgroundLung metastasis is the most adverse clinical factor and remains the leading cause of osteosarcoma-related death. Deciphering the mechanisms...
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Current Insights into Signature MicroRNA Networks and Signal Transduction in Osteosarcoma
Purpose of ReviewOsteosarcoma is one of the most common types of primary bone tumors that mainly occurs in children and adolescents. It is...
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Integration of single-cell sequencing and bulk expression data reveals chemokine signaling pathway in proliferating cells is associated with the survival outcome of osteosarcoma
BackgroundOsteosarcoma, as the most common primary bone malignancy, is urgent to be well-studied on the biomarkers and therapeutic targets to improve...
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Osteosarcoma transcriptome data exploration reveals STC2 as a novel risk indicator in disease progression
BackgroundOsteosarcoma has been the most common primary bone malignant tumor in children and adolescents. Despite the considerable improvement in the...
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Timing of treatment in osteosarcoma: challenges and perspectives – a sco** review
BackgroundThe timing of events in the management of osteosarcoma may be critical for patient survivorship; however, the prognostic value of factors...
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What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance
BackgroundGPR65 is a pH-sensing G-protein-coupled receptor that acts as a key innate immune checkpoint in the human tumor microenvironment,...
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Significance of the neutrophil-to-lymphocyte ratio in predicting the response to neoadjuvant chemotherapy in extremity osteosarcoma: a multicentre retrospective study
BackgroundAt present, no predictive factor has been validated for the early efficacy of neoadjuvant chemotherapy (NACT) in osteosarcoma. The purpose...
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Unusual course of disease and genetic profile in Li-Fraumeni syndrome-associated osteosarcoma – a case report
BackgroundOsteosarcoma is a highly malignant tumour associated with numerous and complex genetic alterations like copy number alterations. Recent...
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Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis
As the most prevalent bone tumor in children and adolescents, the pathogenesis and metastasis of osteosarcoma (OS) remain largely unclear. Here, we...
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Identification and verification of a BMPs-related gene signature for osteosarcoma prognosis prediction
BackgroundThis study aimed to get a deeper insight into new osteosarcoma (OS) signature based on bone morphogenetic proteins (BMPs)-related genes and...
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Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)
The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results...
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Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma
Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made...
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Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma
Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms...
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Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms
BackgroundOsteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially doubling...
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Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database
BackgroundHistorically, amputation was the primary surgical treatment for osteosarcoma of the extremities; however, with advancements in surgical...
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Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing
BackgroundSingle-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages...
