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Adulteration Detection and Quantification in Olive Oil Using Excitation-Emission Matrix Fluorescence Spectroscopy and Chemometrics
This research investigates the use of excitation-emission matrix fluorescence (EEMF) in conjunction with chemometric models to rapidly identify and...
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Defining the Range of Calibration Burden: From Full Calibration to Calibration-Free
The expansion of spectroscopic process analytical technology (PAT) within the pharmaceutical industry requires chemometric models to enable spectral...
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Evaluation and Monitoring of the API Content of a Portable Near Infrared Instrument Combined with Chemometrics Based on Fluidized Bed Mixing Process
PurposeWith the promulgation of industry guidelines, near infrared spectroscopy (NIRS) monitoring the uniformity of solid oral preparations has...
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Ability of near-infrared spectroscopy and chemometrics to predict the age of mosquitoes reared under different conditions
BackgroundPractical, field-ready age-grading tools for mosquito vectors of disease are urgently needed because of the impact that daily survival has...
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Natural Products Drug Discovery: On Silica or In-Silico?
Natural products have been the most important source for drug development throughout the human history. Over time, the formulation of drugs has...
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Adulteration in Oils and Fats Industry
Adulterations in oils and fats is a major food safety issue that affects consumers and food industries. Monitoring the purity of oils and fats has...
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Application of NMR and Chemometric Analyses to Better Understand the Quality Attributes in pH and Thermally Degraded Monoclonal Antibodies
PurposeNuclear magnetic resonance (NMR) spectroscopy provides the sensitivity and specificity to probe the higher order structure (HOS) of monoclonal...
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Application of Spectroscopic and Chromatographic Methods for the Analysis of Non-halal Meats in Food Products
Meat is one of the major food groups which is frequently adulterated for economic reasons. In line with halal certification, the presence of...
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Combination of 3D Fluorescence/PARAFAC and UV–Vis Absorption for the Characterization of Agricultural Soils from Morocco
The present study, combining UV–Visible absorption and 3D fluorescence supported by PARAFAC chemometric analysis, focused on the characterization of...
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Rapid Determination in the Quality Control of Chinese Patent Medicine
PurposeDue to the large number of chemical components in Chinese patent medicine, the quality control analysis is faced with greater challenges....
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Artificial Intelligence and Discovery of Microbial Natural Products
Natural products (NPs) have a variety of potential medicinal applications as drug or lead molecules for drug development. NPs are subset of small...
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Ideal Synbiotics: Pharmacokinetic, Pharmacodynamic, and Safety Assessment
Functional foods are becoming increasingly popular as people become more interested in maintaining their health and preventing diseases. Synbiotics...
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Analytical Quality by Design Fundamentals and Compendial and Regulatory Perspectives
Over the last years, the pharmaceutical industry and regulatory agencies have been embracing the Quality by Design (QbD) principles. Significant...
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Salivary Biomarkers in Toxicology: An Update Narrative
Saliva is a complex biofluid, but also a magical biofluid, because it is a mirror of both oral and general health. Multiple general pathologies (of...
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The Use of Data Mining for Obtaining Deeper Insights into the Fabrication of Prednisolone-Loaded Chitosan Nanoparticles
The present work explores a data mining approach to study the fabrication of prednisolone-loaded chitosan nanoparticles and their properties. Eight...
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Application of Biotechnology in Pharmaceutical Manufacturing Control
Pharmaceutical biotechnology represents a rapidly evolving field wherein biotechnological principles are applied to diverse pharmaceutical...
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NIR Spectroscopy as an Online PAT Tool for a Narrow Therapeutic Index Drug: Toward a Platform Approach Across Lab and Pilot Scales for Development of a Powder Blending Monitoring Method and Endpoint Determination
An online near-infrared (NIR) spectroscopy platform system for real-time powder blending monitoring and blend endpoint determination was tested for...
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Cheminformatics modeling of the correlation between Bupleurum Root-formula medicines and Excess and Deficiency pattern in the diagnostic criteria of Sho in Kampo (traditional Japanese medicine) by non-targeted direct infusion mass spectrometry with machine learning
Kampo is a form of traditional Japanese medicine, and its therapeutic strategy has been validated empirically over millennia, mainly in Asia. Kampo...
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Detection of the Adulteration of Motor Oil by Laser Induced Fluorescence Spectroscopy and Chemometric Techniques
Petroleum products are the target of fraudulent practices due to their high commercial value. The aim of this study is to provide a new analysis...
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The Use of FTIR Spectroscopy Combined with Multivariate Analysis in Food Composition Analysis
Infrared spectroscopy, one of the vibrational spectroscopies, has emerged as rapid and powerful analytical technique for identification and...