Search
Search Results
-
Challenges
Meta-analysis is always criticised for combining diverse types of studies (‘mixing apples with oranges’). There are many challenges in the conduct of...
-
Successes and challenges in clinical gene therapy
Despite the ups and downs in the field over three decades, the science of gene therapy has continued to advance and provide enduring treatments for...
-
Cancer survivorship challenges of rural older adults: a qualitative study
BackgroundAlthough research has advanced the field of oncologic geriatrics with survivors to assess their cancer-related needs and devise...
-
Pharmacogenomics in Lebanon: current status, challenges and opportunities
Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon considering its population genetic diversity. Moreover, as a...
-
Challenges and opportunities in NASH drug development
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), represent a growing worldwide epidemic and a...
-
Climate change and health: three grand challenges
Climate change may be the greatest health threat of the twenty-first century, impacting lives both directly and indirectly, through undermining the...
-
Playing Hide-and-Seek with Tyrosine Kinase Inhibitors: Can We Overcome Administration Challenges?
Tyrosine kinase inhibitors (TKIs) have demonstrated significant efficacy against various types of cancers through molecular targeting mechanisms....
-
Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of...
-
Trisomy silencing by XIST: translational prospects and challenges
XIST RNA is heavily studied for its role in fundamental epigenetics and X-chromosome inactivation; however, the translational potential of this...
-
Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
The CRISPR system is a revolutionary genome editing tool that has the potential to revolutionize the field of cancer research and therapy. The...
-
Emerging Innate Immune Cells in Cancer Immunotherapy: Promises and Challenges
Immune checkpoint inhibitor (ICI)-based therapy has made an unprecedented impact on survival benefit for a subset of cancer patients; however, only a...
-
Challenges, approaches and enablers: effectively triangulating towards dose selection in pediatric rare diseases
Dose selection is an integral part of a molecule’s journey to become medicine. On top of typical challenges faced in dose selection for more common...
-
Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no...
-
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
ObjectivesThe efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction between the device...
-
The role of virtual consultations in cancer genetics: challenges and opportunities introduced by the COVID-19 pandemic
The COVID-19 pandemic changed the delivery of healthcare within the United Kingdom. A virtual model of care, utilising telephone and video...
-
Translational opportunities and challenges of invasive electrodes for neural interfaces
Invasive brain–machine interfaces can restore motor, sensory and cognitive functions. However, their clinical adoption has been hindered by the...
-
Human mesenchymal stem cell secretomes: Factors affecting profiling and challenges in clinical application
The promising field of regenerative medicine is thrilling as it can repair and restore organs for various debilitating diseases. Mesenchymal stem...
-
Disease modification in inflammatory skin disorders: opportunities and challenges
Progress in understanding of the mechanisms underlying chronic inflammatory skin disorders, such as atopic dermatitis and psoriasis vulgaris, has led...
-
Integrating Large Language Models in Bioinformatics Education for Medical Students: Opportunities and Challenges
Large language models (LLMs) offer transformative opportunities in bioinformatics education for medical students by creating interactive experiences....
-
Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors
The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic...
