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Cell-free DNA methylome analysis for early preeclampsia prediction
Preeclampsia (PE) is a leading cause for peripartal morbidity, especially if develo** early in gestation. To enable prophylaxis in the prevention...
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Cell-free DNA for the detection of kidney allograft rejection
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of...
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The role of circulating cell-free DNA as an inflammatory mediator after stroke
Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex...
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Reduced representative methylome profiling of cell-free DNA for breast cancer detection
BackgroundWhole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome...
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Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection
BackgroundRecent advances in circulating cell-free DNA (cfDNA) analysis from biofluids have opened new avenues for liquid biopsy (LB). However,...
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Diagnosing and monitoring pancreatic cancer through cell-free DNA methylation: progress and prospects
Pancreatic cancer is one of the most challenging cancers due to its high mortality rates. Considering the late diagnosis and the limited survival...
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Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids
BackgroundFragmentomics, the investigation of fragmentation patterns of cell-free DNA (cfDNA), has emerged as a promising strategy for the early...
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Microfluidic Acoustic Method for High Yield Extraction of Cell-Free DNA in Low-Volume Plasma Samples
Cell-free DNA has many applications in clinical medicine, in particular in cancer diagnosis and cancer treatment monitoring. Microfluidic-based...
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Prospective prenatal cell-free DNA screening for genetic conditions of heterogenous etiologies
Prenatal cell-free DNA (cfDNA) screening uses extracellular fetal DNA circulating in the peripheral blood of pregnant women to detect prevalent fetal...
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Multimodal epigenetic sequencing analysis (MESA) of cell-free DNA for non-invasive colorectal cancer detection
BackgroundDetecting human cancers through cell-free DNA (cfDNA) in blood is a sensitive and non-invasive option. However, capturing multiple forms of...
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Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
BackgroundKnowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for patient management....
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Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing
Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a...
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Analysis of cell free DNA to predict outcome to bevacizumab therapy in colorectal cancer patients
To predict outcome to combination bevacizumab (BVZ) therapy, we employed cell-free DNA (cfDNA) to determine chromosomal instability (CIN), nucleosome...
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Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detected in many patients using...
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A circulating cell-free DNA methylation signature for the detection of hepatocellular carcinoma
To address the shortcomings of current hepatocellular carcinoma (HCC) surveillance tests, we set out to find HCC-specific methylation markers and...
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Cell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19
BackgroundThe recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellular level in...
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Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA
BackgroundEpigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by...
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Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
BackgroundDNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and...
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Cell-Free RNA Sequencing from Biofluid Samples
Liquid biopsy has obvious advantages over invasive sampling methods. Cell-free DNA is now widely used in prenatal and cancer diagnosis. Cell-free RNA...
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CRAG: de novo characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencing
The fine-scale cell-free DNA fragmentation patterns in early-stage cancers are poorly understood. We developed a de novo approach to characterize the...
