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Piezo1, the new actor in cell volume regulation
All animal cells control their volume through a complex set of mechanisms, both to counteract osmotic perturbations of the environment and to enable...
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The role of spleen volume change in predicting immunotherapy response in metastatic renal cell carcinoma
IntroductionResistance to immune checkpoint inhibitors (ICI) is a significant issue in metastatic renal cell carcinoma (mRCC), as it is in the...
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Block Advance Causes Substantial Error in Stereology Estimates of Cavalieri Volume and Disector-Based Cell Counts
Background: Design-based (unbiased) stereology is considered the best practice for quantifying morphometric parameters of stained biological...
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Reducing and controlling metabolic active tumor volume prior to CAR T-cell infusion can improve survival outcomes in patients with large B-cell lymphoma
Bridging therapy before CD19-directed chimeric antigen receptor (CAR) T-cell infusion is frequently applied in patients with relapsed or refractory...
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Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells
Fast growing solid tumors are frequently surrounded by an acidic microenvironment. Tumor cells employ a variety of mechanisms to survive and...
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Microfluidic Acoustic Method for High Yield Extraction of Cell-Free DNA in Low-Volume Plasma Samples
Cell-free DNA has many applications in clinical medicine, in particular in cancer diagnosis and cancer treatment monitoring. Microfluidic-based...
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A century of exercise physiology: key concepts in muscle cell volume regulation
Skeletal muscle cells can both gain and lose volume during periods of exercise and rest. Muscle cells do not behave as perfect osmometers because the...
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Hair Cell Regeneration
This volume provides a detailed update on progress in the field of hair cell regeneration. This topic is of considerable interest to academicians,...
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Partial-Volume Irradiation of Murine Tumors
Radiotherapy is a widely used approach for cancer treatment. However, delivering a single high dose of radiation to bulky tumors can be challenging...
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Extensive clinical target volume in postoperative chemoradiotherapy for esophageal squamous cell carcinoma: a phase II clinical trial (ESO-Shanghai 9)
BackgroundTo compare the efficacy and safety of postoperative extensive target volume irradiation with elevated radiation dose and concurrent...
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Cancer Cell Culture Methods and Protocols
This volume explores the latest collection of cell models that are used in preclinical cancer research, and covers both two-dimensional and...
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T-Cell Development Methods and Protocols
This second edition volume provides new and updated chapters detailing simple and accessible experiment protocols to explore thymus biology. Chapters...
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The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling
The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is responsible for the regulatory volume decrease (RVD) after hypotonic...
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Primary tumor volume and prognosis for patients with p16-positive and p16-negative oropharyngeal squamous cell carcinoma treated with radiation therapy
BackgroundThe prescribed radiation dose to patients with oropharyngeal squamous cell carcinoma (OPSCC) is standardized, even if the prognosis for...
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The usefulness of the total metabolic tumor volume for predicting the postoperative recurrence of thoracic esophageal squamous cell carcinoma
BackgroundInduction or adjuvant therapies are not always beneficial for thoracic esophageal squamous cell carcinoma (ESCC) patients, and it is thus...
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Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume
We studied the effects of glycyrrhetinic acid (bioactive aglycone of glycyrrhizin) and its ester derivatives at positions C-3 and C-30 on the cell...
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Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification
The volume-sensitive outwardly rectifying or volume-regulated anion channel, VSOR/VRAC, which was discovered in 1988, is expressed in most vertebrate...
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Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma
BackgroundThe expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression...
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Single-Cell Ca2+ Imaging
In rheumatological studies, visualization of Ca2+ dynamics in intact cells as direct experimental evidence of Ca2+-dependent signal pathways is...