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Interfaces to Control Cell-Biomaterial Adhesive Interactions
Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices,...
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The diversification of methods for studying cell–cell interactions and communication
No cell lives in a vacuum, and the molecular interactions between cells define most phenotypes. Transcriptomics provides rich information to infer...
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Cell Aggregation Assays for Homophilic Interactions Between Cell Surface Proteins
Many proteins expressed on the cellular surface provide signaling and cell adhesion properties required for vital cellular functions. These binding...
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Enhancer–promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation
To regulate expression, enhancers must come in proximity to their target gene. However, the relationship between the timing of enhancer–promoter...
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Cognate microglia–T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology
Microglia, the parenchymal brain macrophages of the central nervous system, have emerged as critical players in brain development and homeostasis....
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Generating Human Pluripotent Stem Cell-Derived Neural AssemBloids™ to Model Interneuron Migration and Immune Cell Interactions
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs) have emerged as an innovative model to study the central...
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Physical Regulations of Cell Interactions and Metabolism in Tumor Microenvironments
Despite the advances in cancer therapeutics over the recent years, cancer remains the second leading cause of death in the United States, with...
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High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line
BackgroundThe development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often...
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Comprehensive investigation of malignant epithelial cell-related genes in clear cell renal cell carcinoma: development of a prognostic signature and exploration of tumor microenvironment interactions
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy with complex heterogeneity within epithelial cells, which plays a crucial role in...
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Electrical cell-substrate impedance sensing (ECIS) as a tool to study microbial-cell interactions
ECIS is an impedance-based method to study the cellular responses to a stimulus. Manipulating the alternating current frequencies in ECIS helped...
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Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration
Skeletal muscles have an extraordinary capacity to regenerate themselves when injured. Skeletal muscle stem cells, called satellite cells, play a...
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FOLFIRINOX Pharmacodynamic Interactions in 2D and 3D Pancreatic Cancer Cell Cultures
The multi-drug combination regime, FOLFIRINOX, is a standard of care chemotherapeutic therapy for pancreatic cancer patients. However, systematic...
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In Vitro Visualization of Cell-to-Cell Interactions Between Natural Killer Cells and Sensory Neurons
Cell-to-cell interactions between the immune and nervous systems are increasingly recognized for their importance in health and disease. Assessment...
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Chemokine-Glycosaminoglycan Interactions Methods and Protocols
This detailed volume provides methods to guide assay development, procedures designed to investigate the chemokine and glycosaminoglycan (GAG)...
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Virus-Host Interactions Methods and Protocols
This detailed volume spotlights methods to investigate a variety of virus-host interactions in humans, other mammals, fish, or insects. It explores...
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TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell development. Although in vitro biochemical assays suggest that...
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Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions
BackgroundAge and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue...
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Organoid Co-culture Methods to Capture Cancer Cell–Natural Killer Cell Interactions
Metastasis is a complex process that has been historically difficult to model in culture. Host immune responses play critical roles in restraining...
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Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses....
