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Regulation of T Cell Response in Inflammation from Killing to Healing
T cells and their subsets play a crucial role in optimizing immune response against inflammation, but impairment of its regulation can contribute to...
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Single-cell profiling of response to neoadjuvant chemo-immunotherapy in surgically resectable esophageal squamous cell carcinoma
BackgroundThe efficacy of neoadjuvant chemo-immunotherapy (NAT) in esophageal squamous cell carcinoma (ESCC) is challenged by the intricate interplay...
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Novel insights into the immune response to bacterial T cell superantigens
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to activate large numbers of T cells simultaneously. SAgs...
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Inflammatory response-based prognostication and personalized therapy decisions in clear cell renal cell cancer to aid precision oncology
ObjectiveThe impact of inflammatory response on tumor development and therapeutic response is of significant importance in clear cell renal cell...
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Integrated analysis of single-cell and bulk RNA sequencing data reveals a myeloid cell-related regulon predicting neoadjuvant immunotherapy response across cancers
BackgroundImmunotherapy has brought about a paradigm shift in the treatment of cancer. However, the majority of patients exhibit resistance or become...
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Human Cancer Cell Radiation Response Investigated through Topological Analysis of 2D Cell Networks
Clonogenic assays are routinely used to evaluate the response of cancer cells to external radiation fields, assess their radioresistance and...
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Map** interindividual dynamics of innate immune response at single-cell resolution
Common genetic variants across individuals modulate the cellular response to pathogens and are implicated in diverse immune pathologies, yet how they...
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Choroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage
BackgroundIntraventricular hemorrhage (IVH) and associated hydrocephalus are significant complications of intracerebral and subarachnoid hemorrhage....
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Impaired B Cell Recall Memory and Reduced Antibody Avidity but Robust T Cell Response in CVID Patients After COVID-19 Vaccination
PurposeHumoral and cellular immune responses were described after COVID-19 vaccination in patients with common variable immunodeficiency disorder...
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Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics
Cancer is a disease that undergoes selective pressure to evolve during its progression, becoming increasingly heterogeneous. Tumoral heterogeneity...
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Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer
BackgroundLung cancer is the most lethal cancer, and 85% of cases are classified as non-small cell lung cancer (NSCLC). Metabolic rewiring is a...
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Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics, but the underlying mechanism...
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Analysis of the Adherent Cell Response to the Substrate Stiffness Using Tensegrity
Cell’s shape is dependent on the cytoskeleton mechanical properties. Hybrid models were developed that combine the discrete structure for the...
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Exosomal miRNA-146a and miRNA-424 as Possible Predictors of Immune Checkpoint Inhibitors Therapy Response in Clear Cell Renal Cell Carcinoma
AbstractClear cell renal cell carcinoma (ccRCC) is a malignant kidney tumour with a poor prognosis and difficult to treat. Despite significant...
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Update on B Cell Response in Periodontitis
B cells have a central and dual role in the physio-pathological mechanisms of periodontitis. They take part in the elimination of the periodontal...
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Immune Response
The specific reactivity induced by an antigenic stimulus in a host is known as an immune response. The immune system is developed in a host primarily...
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Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
AbstractMicrofluidic platforms for clinical use are a promising translational strategy for cancer research specially for drug screening. Identifying...
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Response of Therapy in Cell-Cycle Regulatory Genes in Breast Cancer
Dysregulation of the cell cycle, which permits for unrestricted cellular division, is a characteristic of cancer. Cells develop genetic changes that...
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The Immune Response
The process of viral infection having been briefly described, it is important to present the mechanisms involved in the immune response of the...
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Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection
Regulatory T (T reg ) cell modulation of adaptive immunity and tissue homeostasis is well described; however, less is known about T reg cell-mediated...
