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A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Following acute injury, stromal cells promote tissue regeneration by a diversity of mechanisms. Time-resolved single-cell RNA sequencing of muscle...
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Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways
BackgroundInfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more...
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Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to immune checkpoint...
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Introduction to Cell Signaling Pathways and Brain Tumors
Cell signaling is the process by which cells coordinate and communicate with other cells, allowing cells to act in the correct way in response to...
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TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease
ObjectiveTo figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD).
MethodsPlasma TSLP levels were tested...
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Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders
Despite the availability of an effective vaccine and antiviral treatments, hepatitis B is still a global public health problem. Hepatitis B...
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Evolution of delayed resistance to immunotherapy in a melanoma responder
Despite initial responses
1 –3 , most melanoma patients develop resistance4 to immune checkpoint blockade (ICB). To understand the evolution of...
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scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
BackgroundIneffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are...
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Identification of CD8+ T-cell exhaustion signatures for prognosis in HBV-related hepatocellular carcinoma patients by integrated analysis of single-cell and bulk RNA-sequencing
BackgroundHBV infection is the leading risk factor for HCC. HBV infection has been confirmed to be associated with the exhaustion status of CD8 + T...
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Blood-based molecular and cellular biomarkers of early response to neoadjuvant PD-1 blockade in patients with non-small cell lung cancer
BackgroundDespite the improved survival observed in PD-1/PD-L1 blockade therapy, a substantial proportion of cancer patients, including those with...
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A phase Ib/II study of galunisertib in combination with nivolumab in solid tumors and non-small cell lung cancer
BackgroundIn this phase Ib/II open-label study, tumor immune suppression was targeted in patients with advanced refractory solid tumors and patients...
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Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results
The T cell receptor fusion construct (TRuC) gavocabtagene autoleucel (gavo-cel) consists of single-domain anti-mesothelin antibody that integrates...
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Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients
Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical...
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Occurrence of Existing BCR-ABL Baseline Mutations and Associated Haplotype (NmR) Among CML Patients with Diverse IM Response: A Hospital-based Study from North-East India
Highly polymorphic BCR-ABL kinase domains have been reported to harbor more than a hundred mutations, and among these, 40–60% have been identified as...
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Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
BackgroundAbout 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need...
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A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma
An important challenge in the real-world management of patients with advanced clear-cell renal cell carcinoma (aRCC) is determining who might benefit...
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Impaired B Cell Recall Memory and Reduced Antibody Avidity but Robust T Cell Response in CVID Patients After COVID-19 Vaccination
PurposeHumoral and cellular immune responses were described after COVID-19 vaccination in patients with common variable immunodeficiency disorder...
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Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome system
We previously reported that dendritic cells (DCs) transduced with the full-length tumor-associated antigen (TAA) gene induced TAA-specific cytotoxic...
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Factor of time in dendritic cell (DC) maturation: short-term activation of DCs significantly improves type 1 cytokine production and T cell responses
Dendritic cells (DCs) have been intensively studied in correlation to tumor immunology and for the development DC-based cancer vaccines. Here, we...
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Whole transcriptome analysis to explore the impaired immunological features in critically ill elderly patients with sepsis
BackgroundSepsis is a frequent complication in critically ill patients, is highly heterogeneous and is associated with high morbidity and mortality...
