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Murine leukemia virus (MLV) P50 protein induces cell transformation via transcriptional regulatory function
BackgroundThe murine leukemia virus (MLV) has been a powerful model of pathogenesis for the discovery of genes involved in cancer. Its splice donor...
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PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model
Acute myeloid leukemia (AML) is a malignant hematologic disease caused by gene mutations and genomic rearrangements in hematologic progenitors. The...
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Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV...
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Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells
BackgroundPromyelocytic leukemia protein (PML) is a primary component of PML nuclear bodies (PML-NBs). PML and PML-NBs play critical roles in...
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Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression
BackgroundActivated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which...
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Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation
IntroductionHuman T-cell Lymphotropic virus type 1 (HTLV-1) belongs to retroviridae which is connected to two major diseases, including...
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Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival
Adult T cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic infection with human T cell leukemia virus type 1 (HTLV-1). The...
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Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell leukemia virus type I (HTLV-I). There...
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Molecular analysis of the env, LTR, and pX regions of bovine leukemia virus in dairy cattle of Türkiye
Bovine leukemia virus is a retrovirus that causes enzootic bovine leukosis and is associated with global economic losses in the livestock industry....
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HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
PurposeLeukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number of cancer patients....
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Sequence variation of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene in chronic lymphocytic leukemia and healthy volunteer subjects
Epstein-Barr virus–related malignancies have been linked to variations in the sequences of EBV genes, notably EBNA1. Therefore, the purpose of this...
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Endogenous feline leukemia virus long terminal repeat integration site diversity is highly variable in related and unrelated domestic cats
Endogenous retroviruses (ERV) are indicators of vertebrate evolutionary history and play important roles as homeostatic regulators. ERV long terminal...
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A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation
Bovine Leukemia Virus (BLV) is the etiological agent of enzootic bovine leukosis, a disease characterized by the neoplastic proliferation of B cells...
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Zidovudine and Interferon Alfa based regimens for the treatment of adult T-cell leukemia/lymphoma (ATLL): a systematic review and meta-analysis
BackgroundATLL (Adult T-Cell Leukemia/Lymphoma) is an aggressive hematological malignancy. This T-cell non-Hodgkin lymphoma, caused by the human...
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Upregulation of host genes during disease progression in bovine leukemia virus infection is independent of overexpression of viral transcriptional regulators in vitro
Bovine leukemia virus (BLV) is a member of the genus Deltaretrovirus within the family Retroviridae that infects bovine B cells, causing persistent...
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Assessment of Ecotropic Viral Integration Site 2B (EVI2B) Gene in Juvenile Myelomonocytic Leukemia and Neurofibromatosis Type 1 NF1 Tumors
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that affects the development and growth of various tissues. NF1 is a major risk...
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Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood
A massive increase in the number of mature CD4 + T-cells in peripheral blood (PB) is a defining characteristic of acute type of adult T-cell leukemia...
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An Overview of the Cell Biology and Genetic Barriers to Virus Infections with Implications in Cell Line Development for Virotherapy
Viruses can be engineered for oncolysis, gene therapy, or vaccines. Oncolytic viruses and viral vector for cell and gene therapies are promising...
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Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients
Second allogeneic stem cell transplantation (alloSCT2) is among the most effective treatments for acute myeloid leukemia (AML) relapse after first...
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Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia
BackgroundEnhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of...
