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Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases
Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type, making them a powerful in vitro model for human biology....
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Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4 + helper T (Th) cells are central to the balance between immune tolerance and immune...
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Cancer Cell Biology Methods and Protocols
This volume provides detailed methods on the mechanisms of underlying cancer cell biology. Chapters guide readers through techniques for culturing...
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Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
The circadian system is a conserved time-kee** machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and...
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A new era of stem cell and developmental biology: from blastoids to synthetic embryos and beyond
Recent discoveries in stem cell and developmental biology have introduced a new era marked by the generation of in vitro models that recapitulate...
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Metabolomics in Cell Biology
Metabolomics has long been used in a biomedical context. The most typical samples are body fluids in which small molecules can be detected and...
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Modeling the Cell Biology of Prions
Cell models have been useful for elucidating the function of proteins and/or their role in pathogenesis. Even before the discovery that the prion...
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Localization, tissue biology and T cell state — implications for cancer immunotherapy
Tissue localization is a critical determinant of T cell immunity. CD8 + T cells are contact-dependent killers, which requires them to physically be...
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Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
BackgroundSystemic therapy for metastatic clear cell sarcoma (CCS) bearing EWSR1-CREB1/ATF1 fusions remains an unmet clinical need in children,...
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Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough solutions to problems such as protein structure prediction...
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Osteoclast biology in the single-cell era
Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such...
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Applications of Machine Learning in Study of Cell Biology
The study of cell biology is extremely complex involving the diverse structural, functional features, development, differentiation, metabolism, and...
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Chemical Biology of Extracellular Vesicles
During the initial phases of extracellular vesicle (EV) research, researchers faced many obstacles, including a lack of standard methods for the...
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Cell Biology and Cell Behavior in Cancer
Cell is the basic unit of a living organism. This chapter focuses on the structure and functionalities of a typical eukaryotic cell. Inside a...
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Histochemistry and Cell Biology—a glance into the past and a look ahead
At the occasion of the 65th anniversary of Histochemistry and Cell Biology , we browse through its first ten years of publication and highlight a...
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Gastric Stem Cell Biology and Helicobacter pylori Infection
Helicobacter pylori colonizes the human gastric mucosa and persists lifelong. An interactive network between the bacteria and host cells shapes a...
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The cell biology of HIV-1 latency and rebound
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4 + T cells, pose the primary...
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The Power of Translational Biology
Translational biology, the bridge between fundamental research and practical applications in medicine, has entered an era of unprecedented...
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An Overview of the Cell Biology and Genetic Barriers to Virus Infections with Implications in Cell Line Development for Virotherapy
Viruses can be engineered for oncolysis, gene therapy, or vaccines. Oncolytic viruses and viral vector for cell and gene therapies are promising...
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Multiplex protein imaging in tumour biology
Tissue imaging has become much more colourful in the past decade. Advances in both experimental and analytical methods now make it possible to image...
