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Incidence and risk factors for mortality in patients treated with combined ceftaroline for Gram-positive infective endocarditis
BackgroundCeftaroline is a fifth-generation cephalosporin and represents an alternative in the treatment of infective endocarditis (IE). The main...
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Impact on in-hospital mortality of ceftaroline versus standard of care in community-acquired pneumonia: a propensity-matched analysis
The purpose of this study is to evaluate the in-hospital mortality of community-acquired pneumonia (CAP) treated with ceftaroline in comparison with...
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Characterization of an osteomyelitis case caused by dalbavancin, ceftaroline, and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus
We report a case of osteomyelitis due to methicillin-resistant Staphylococcus aureus (MRSA) that is also non-susceptible to vancomycin, dalbavancin,...
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Global trends of antimicrobial susceptibility to ceftaroline and ceftazidime–avibactam: a surveillance study from the ATLAS program (2012–2016)
BackgroundThis study reports the global trends of antimicrobial susceptibility to ceftaroline and ceftazidime–avibactam using data from the...
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New Cephalosporins: Fifth and Sixth Generations
New generation (5th) of cephalosporins have been introduced on the market over the last decade to combat methicillin-resistant Staphylococcus aureus...
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A comparison of daptomycin alone and in combination with ceftaroline fosamil for methicillin-resistant Staphylococcus aureus bacteremia complicated by septic pulmonary emboli
The use of daptomycin (DAP) in septic pulmonary emboli (SPE) remains controversial. We analyzed 29 cases of MRSA bacteremia complicated by SPE...
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Differential effects of antibiotics on neutrophils exposed to lipoteichoic acid derived from Staphylococcus aureus
BackgroundPersistent bacteremia occurs in at least 30% of patients with Staphylococcus aureus bloodstream infection (SAB) and may be attributable to...
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A New Fluoroquinolone: Delafloxacin
The fluoroquinolones have been in clinical use for over 50 years for community- and hospital-associated infections, but widespread, often...
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Recurrent bacteremia and endocarditis due to Staphylococcus capitis in a patient with Bowen’s disease: a case report
This case report details the management of a 79-year-old male with recurrent methicillin-resistant Staphylococcus capitis bacteremia and...
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An Update on Advancements in Treatment Options for Managing Klebsiella pneumoniae Infections
Purpose of ReviewKlebsiella pneumoniae is a significant gram-negative opportunistic pathogen, which causes a variety of infectious diseases,...
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Antimicrobial Resistance: An Overview
Recounting the struggle against infectious diseases reconciles us with the failures. Following discovery, clinical implementation of different...
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Penicillin-binding proteins: the master builders and breakers of bacterial cell walls and its interaction with β-lactam antibiotics
Penicillin-binding proteins (PBPs) have been the subject of analysis for over 40 years. These proteins play a crucial role in catalyzing...
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Pandemic clone USA300 in a Brazilian hospital: detection of an emergent lineage among methicillin-resistant Staphylococcus aureus isolates from bloodstream infections
BackgroundStaphylococcus aureus is one of the leading causes of bloodstream infections (BSI) worldwide. In Brazil, the hospital-acquired...
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New Oxazolidinone: Tedizolid
Tedizolid is a new member of the oxazolidinone class of synthetic antimicrobial developed over 30 years ago. Linezolid is the first member of the...
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Green-Synthesized Nanoparticles to Combat Multidrug-Resistant Bacteria
Antibiotic resistance has rapidly climbed in recent years, threatening millions of lives worldwide and presenting a serious threat to community...
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Phenotypic and genomic characteristics of oxacillin-susceptible mecA-positive Staphylococcus aureus, rapid selection of high-level resistance to beta-lactams
The aim of this study is to describe the phenotypic and genetic properties of oxacillin-susceptible methicillin-resistant Staphylococcus aureus ...
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Antimicrobial activity of dalbavancin against Gram-positive bacteria isolated from patients hospitalized with bloodstream infection in United States and European medical centers (2018–2020)
Dalbavancin and comparators were susceptibility tested against 8643 Gram-positive bacteria from 74 hospitals located in Europe and the United States...
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Vancomycin and Methicillin Resistance in Staphylococcus aureus: What Is the Next?
Initially four decades ago, Staphylococcus aureus caused infections in clinical and civic situations. This microbe has instigated a significant...
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Vancomycin and Methicillin Resistance in Staphylococcus aureus: What Is the Next?
Initially four decades ago, Staphylococcus aureus caused infections in clinical and civic situations. This microbe has instigated a significant...