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A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019 (COVID-19)...
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Severe polymicrobial and fungal periprosthetic osteomyelitis persisting after hip disarticulations treated with caspofungin in risk patients: a case series
BackgroundPeriprosthetic fungal infections are considered rare and opportunistic infections. Treatment is difficult, and established standards do not...
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Caspofungin Effects on Electrocardiogram of Mice: An Evaluation of Cardiac Safety
Caspofungin is an echinocandin, exhibiting efficacy against most Candida species invasive infection. Its cardiotoxicity was reported in isolated rat...
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A Brief Insight into Peptide and Non-Peptide Drugs of Fungal Origin
Microorganisms are valuable resources for obtaining bioactive compounds, which have proven to be very useful in various domains, e.g., agriculture,...
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Pulmonary surfactant impacts in vitro activity of selected antifungal drugs against Candida krusei and Candida albicans
PurposeThis study investigates how surfactants affect the in-vitro anti-infective efficacy of micafungin, caspofungin, anidulafungin, and...
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Strategies for Enhancing the Production of Echinocandin
Fungi are well known for their ability to naturally produce a multitude of secondary metabolites (SMs) which act as a weapon of defense to protect...
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Analyzing Different Elution Profiles of Echinocandins In Vitro from the Antibiotic-Loaded Bone Cement Comprising Apatite or Polymethylmethacrylate
PurposeThis study aimed to examine the in vitro elution profiles of echinocandins, micafungin and caspofungin, obtained from antibiotic-loaded bone...
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Comparison of in vitro activities of newer triazoles and classic antifungal agents against dermatophyte species isolated from Iranian University Hospitals: a multi-central study
BackgroundDermatophytes have the ability to invade the keratin layer of humans and cause infections. The aims of this study were the accurate...
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Network meta-analysis of triazole, polyene, and echinocandin antifungal agents in invasive fungal infection prophylaxis in patients with hematological malignancies
Background and aimTriazole, polyene, and echinocandin antifungal agents are extensively used to treat invasive fungal infections (IFIs); however, the...
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A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against Aspergillus Fumigatus
Human fungal infections caused by molds have been on the rise in recent years. These infections have high mortality rates compared to other fungal...
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New Systemic Antifungal: Isavuconazole
Invasive fungal infections have been increasing with the increased use of immunosuppressive drugs for the treatment of cancer, organ, stem cell and...
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Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology
BackgroundPrevious studies achieved low microbial detection rates in lymphoma patients with interstitial pneumonia (IP) after chemotherapy. However,...
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The prevalence of multidrug resistance in uropathogens of patients admitted in the intensive care unit of a tertiary care hospital
Urinary tract infections (UTIs) are among the most common bacterial infections, posing significant public health challenges due to increasing...
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Clinical epidemiology of pulmonary aspergillosis in hospitalized patients and contribution of Cyp51A, Yap1, and Cdr1B mutations to voriconazole resistance in etiologic Aspergillus species
Pulmonary aspergillosis is a life-threatening fungal infection with worldwide distribution. In the present study, clinical epidemiology of pulmonary...
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Antifungal
Antifungal classification: 1. Polyenes. (a) Amphotericin B; 2. Flucytosine; 3. Triazoles: Triazoles are heterocyclic compounds, having a...
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The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid
Fungal infections due to Apiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection...
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New Antifungal Drugs: Discovery and Therapeutic Potential
There has been an increase in invasive fungal infections, which are a universal problem due to the longer average lifespan, the number of...
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Clinical characteristics and prognostic risk factors of candidemia in non-neutropenic patients: a retrospective cohort study
This study aimed to determine the clinical characteristics and the prognostic risk factors in non-neutropenic patients with candidemia. Data were...
