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The clinical potential of articular cartilage-derived progenitor cells: a systematic review
Over the past two decades, evidence has emerged for the existence of a distinct population of endogenous progenitor cells in adult articular...
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Cartilage Regeneration
The treatment of damage to cartilage represents one of the most challenging clinical tasks due to the limited spontaneous healing and regenerative...
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Regeneration of Articular Cartilage
Loss of articular cartilage from the ends of bones forming diarthrodial joints can be the source of profound pain and disability, and eventually lead...
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Modification of mesenchymal stem cells for cartilage-targeted therapy
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the destruction of the articular cartilage, sclerosis of the subchondral...
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Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity
BackgroundBecause of its poor intrinsic repair capacity, articular cartilage seldom heals when damaged.
Main bodyRegenerative treatment is expected...
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Conditioned media derived from human fetal progenitor cells improves skin regeneration in burn wound healing
Stem cells are known to have excellent regenerative ability, which is primarily facilitated by indirect paracrine factors, rather than via direct...
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Adult Stem Cells as a Biomarker in Diabetes
Obesity, diabetes, and cardiovascular diseases (CVD) are increasing rapidly worldwide. It is important to know the effect of exercise, medications...
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Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells
Cartilage has little intrinsic capacity for repair, so transplantation of exogenous cartilage cells is considered a realistic option for cartilage...
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Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear,...
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The superficial zone of articular cartilage
The superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as...
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Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells
Mesenchymal progenitor cells (MPCs) have been recently identified in human and murine epidural fat and have been hypothesized to contribute to the...
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Human adipose-derived stromal/stem cells expressing doublecortin improve cartilage repair in rabbits and monkeys
Localized cartilage lesions in early osteoarthritis and acute joint injuries are usually treated surgically to restore function and relieve pain....
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Isolation and Culture of Periosteum-Derived Progenitor Cells from Mice
This chapter describes the methods of isolation of mouse periosteal progenitor cells. There are three basic methods utilized. The bone grafting...
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Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discovered LNA043—a derivative of...
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Integrating bioprinting, cell therapies and drug delivery towards in vivo regeneration of cartilage, bone and osteochondral tissue
The biological and biomechanical functions of cartilage, bone and osteochondral tissue are naturally orchestrated by a complex crosstalk between...
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Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes – Then and Now
Cartilagescartilage are unique in the family of connective tissuesTissue in that they contain a high concentration of the...
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Inflammatory and Anti-Inflammatory Cytokine Activity in the Cartilage Cells of Genetically Modified Mice
AbstractVarious genes level of activity in monolayer cultures of chondroprogenitor cells and chondrocytes isolated from articular cartilage of...
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Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage
Treatments for osteoarthritis would benefit from the enhanced visualization of injured articular cartilage and from the targeted delivery of...
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Adult Stem Cells as a Biomarker in Diabetes
Obesity, diabetes, and cardiovascular diseases (CVD) are increasing rapidly worldwide. It is important to know the effect of exercise, medications...
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Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing
BackgroundOsteoarthritis (OA) is one of the most prevalent joint diseases of advanced age and is a leading cause of disability worldwide. Ageing is a...
