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Delayed cartilage oligomeric matrix protein response to loading is associated with femoral cartilage composition post-ACLR
PurposeTo determine associations between immediate and delayed response of serum cartilage oligomeric matrix protein (sCOMP) to loading (i.e., 3000...
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Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
BackgroundCartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its...
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Periostin regulation and cartilage degradation early after anterior cruciate ligament reconstruction
Objective and designThe purpose of this study was to explore pathological processes during the first 4 weeks after anterior cruciate ligament...
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3D Bioprinting Strategies for Articular Cartilage Tissue Engineering
Articular cartilage is the avascular and aneural tissue which is the primary connective tissue covering the surface of articulating bone. Traumatic...
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Mechanical Articular Cartilage Injury Models and Their Relevance in Advancing Therapeutic Strategies
This chapter details how Alan Grodzinsky and his team unraveled the complex electromechanobiological structure-function relationships of articular...
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Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration
Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan. Aggrecan...
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Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a sco** review
BackgroundThis study aimed to provide an overview of ultrasonographic cartilage evaluation in patients with rheumatoid arthritis (RA) and identify...
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Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discovered LNA043—a derivative of...
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Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear,...
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Metformin as adjuvant therapy in obese knee osteoarthritis patients
AimsThis study aimed at investigating the efficacy of metformin as adjuvant therapy for obese knee osteoarthritis (OA) patients, considering its...
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Extracellular matrix in intervertebral disc: basic and translational implications
Intervertebral disc (IVD) degeneration (IVDD) is the most common spinal disorder, which can lead to the symptoms of neck pain or low back pain. In...
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Characterising the Cytokine and Circulating Immune Cell Response After a Single Bout of Eccentric Step** Exercise in Healthy Untrained Males
PurposeThe mechanisms that underpin exercise-induced muscle damage and recovery are believed to be mediated, in part, by immune cells recruited to...
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Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy
The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation....
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An exploratory study to investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in adult males
PurposeTo investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in a...
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COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-β Signaling Pathway
Cartilage oligomeric matrix protein (COMP) regulates transforming growth factor-β (TGF-β) signaling pathway, which has been proved to be associated...
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Bioactive extracellular matrix fragments in tendon repair
Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia,...
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Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis
Biologics have become increasingly prominent as therapeutics in recent years due to their innate immune-privileged nature, biocompatibility, and high...
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Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis
Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disorder caused by mutations in the Dystrophin gene and for which there is currently no...
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Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis
BackgroundOsteoarthritis (OA) is a degenerative joint disease with lacking effective prevention targets. A disintegrin and metalloproteinase with...
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The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important roles related to the hallmarks...
