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Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis
BackgroundIn recent years, non-alcoholic steatohepatitis (NASH) has become the main cause of hepatocellular carcinoma (HCC). As a means of improving...
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Toward the Integrated Health Risk Assessment of Chemicals
In previous chapters, there are chemicals categorized as carcinogenic, endocrine-disrupting, and nano-size substances. Estimating the safe dose of...
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Risk Assessment and Risk-Benefit Assessment
The framework of risk analysis has become the principal procedure for dealing with food safety issues. Risk analysis consists of three components:...
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Extrapolation-Procedures for Carcinogenic and Noncarcinogenic Compounds
One fundamental goal of regulatory toxicology is to establish safe levels of human exposure to toxic compounds. This is usually performed within the...
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Extrapolation Procedures for Carcinogenic and Noncarcinogenic Compounds
One fundamental goal of regulatory toxicology is to establish safe levels of human exposure to toxic compounds. This is usually performed within the...
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Relative risk of childhood and adolescence cancer in Iran: spatiotemporal analysis from 1999 to 2016
ObjectiveCancer is the third leading cause of death in the world with increasing trends in Iran. The study of epidemiology, trend, and geospatial...
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Safety and Risk Assessment of Food Items
This chapter deals with the use of risk assessments associated with foods in the context of local dietary practices, the absence of which may result...
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Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta
Chemical carcinogens to humans have been usually identified by epidemiological studies on the relationships between occupational or environmental...
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Human Health Risk Assessment (HHRA) for Environmental Exposure: A Brief Account
Exposure of humans to the polluted environment leads to various health ailments and this is a leading matter of concern for researchers and...
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Excess pancreatic cancer risk due to smoking and modifying effect of quitting smoking: The Multiethnic Cohort Study
PurposeRisk factors for pancreatic cancer include racial/ethnic disparities and smoking. However, risk trajectories by smoking history and...
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The incidence risk of gynecological cancer by antipsychotic use: a meta-analysis of 50,402 patients
BackgroundFemale gynecological cancers represent a serious public health problem, with 1,398,601 new diagnoses and 671,875 deaths per year worldwide....
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Integration of Health Risk Assessment for Various Chemicals: Common Biomarkers in Different Exposure Routes
In the previous chapter, we can demonstrate rat hyperactivity through endocrine disruptors. In this chapter, it is shown that rat hyperactivity is...
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Risk assessment of aflatoxin B1 in herbal medicines and plant food supplements marketed in Malaysia using margin of exposure and RISK21 approaches
Aflatoxin B 1 (AFB 1 ) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study...
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Toxicological Risk Assessment
Risk analysis encompasses the scientific review and evaluation of all relevant scientific data on the toxicity of, and the exposure to, a certain...
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Circulating lipids, lipid-lowering drug targets, and breast cancer risk: Comprehensive evidence from Mendelian randomization and summary data-based Mendelian randomization
BackgroundBreast cancer (BC) is the most common and fatal cancer among women, yet the causal relationship between circulating lipids, lipid-lowering...
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Rodent Carcinogenicity Studies
Rodent lifetime carcinogenicity studies are used to assess the carcinogenic potential of chemicals and pharmaceuticals to humans and are a regulatory...
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Risk assessment and prediction for lung cancer among Hong Kong Chinese men
ObjectiveMost of the previous risk prediction models for lung cancer were developed from smokers, with discriminatory power ranging from 0.57 to...
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Environmental and human health risk of heavy metals in atmospheric particulate matter (PM10) around gas flaring vicinity in Bayelsa State, Nigeria
BackgroundExposure to elevated concentrations of heavy metal micro-pollutants is a serious environmental issue. Often times, metals are suspended in...
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Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma
BackgroundOsteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confirmed are to the...
