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A Mouse Model of Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma Induced by Western Diet and Carbon Tetrachloride
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD). Obesity is a known risk factor of NASH, which, in...
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Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt/β-Catenin Signaling Pathway
Liver fibrosis (LF) is caused by the chronic wound healing response to liver injury from various origins. Among the causes, inflammatory response is...
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Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
AbstractHepatic fibrosis (HF) could be developed into liver cirrhosis or even hepatocellular carcinoma. Stress has an important role in the...
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Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4
Liver fibrosis occurs during wound healing after repeated liver injury and is characterized by extensive extracellular matrix deposition. We...
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Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or...
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Indole-3-carbinol alleviates carbon tetrachloride-induced liver injury by inhibiting inflammatory response and regulating lipid metabolism
The hepatoprotective effects of indole-3-carbinol (I3C), one of the byproducts of the breakdown of glucosinolate glucobrassicin, were examined in...
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Substitutions on Saturated Carbon Atom
The theory of reaction mechanisms is explained in more details on the examples of nucleophilic and radical substitutions on the saturated carbon...
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Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats
ObjectiveThis study evaluated hepatoprotective effect of aescin (AES) and diosmin (DIO), individually or in low-dose combination in chemically...
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β-Sitosterol attenuates carbon tetrachloride–induced oxidative stress and chronic liver injury in rats
Chronic liver diseases are clinically silent and responsible for significant morbidity and mortality worldwide. β-Sitosterol (BSS), major phytosterol...
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Recent Progress of Fluorescent Carbon Dots and Graphene Quantum Dots for Biosensors: Synthesis of Solution Methods and their Medical Applications
In the fields of health and biology, fluorescent nanomaterials have emerged as highly potential and very useful candidates for use in biosensor...
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Facile Synthesis of Carbon Dots from Biomass Material and Multi-Purpose Applications
Selective and sensitive water content measurement in organic solvents is extremely significant for both industrial use and laboratory preparation....
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Gene expression regulating the cell cycle and gene of antioxidant protection system in toxic hepatitis
BackgroundIn the present study, we examined the changes in gene expression regulating the cell cycle and the gene of antioxidant protection system in...
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Hepatoprotective effect and possible mechanism of phytoestrogen calycosin on carbon tetrachloride–induced liver fibrosis in mice
The study was to explore the hepatoprotective effect and possible mechanism of calycosin on carbon tetrachloride (CCl 4 )–induced liver fibrosis in...
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Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination
Toxicant-induced injury is a significant global health issue. However, the mechanisms through which toxicants such as carbon tetrachloride,...
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Fluorescent Mechanism in Zero-Dimensional Carbon Nanomaterials: A Review
Fluorescent carbon dots (CDs) have acquired growing interest from different areas over decades. Their fascinating property of tunable fluorescence by...
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Appraisal of Acalypha wilkesiana Godseffiana mitigating effects against carbon tetrachloride (CCl4)-induced oxidative impairment in female wistar rat
AbstractAcalypha wilkesiana godseffiana Mull arg leaf is traditionally used among Yorubas in Southern Nigeria for the treatment of malaria,...
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Age-Related Features of the Viscosity of Plasma and Mitochondrial Membranes of Hepatocytes in Liver Cirrhosis
The viscosity of plasma and mitochondrial membranes of hepatocytes was studied in young (3-month-old) and old (9-month-old) male Wistar rats. It was...
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Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway
Angelica dahurica (A. dahurica) has a wide range of pharmacological effects, including analgesic, anti-inflammatory and hepatoprotective effects. In...
